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Showing 1–14 of 14 results
Advanced filters: Author: Jan Mauer Clear advanced filters

  • This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.

    • Pragati Kore
    • Michael W. Wilson
    • Elizabeth G. Atkinson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Cells employ different repair pathways to repair DNA double strand breaks. Here, the authors develop a CRISPR/Cas9-dependent method to study choices in DNA repair called the Color Assay Tracing-Repair (CAT-R) which simultaneously measure outcomes of DSB repair via end-protection and end-resection pathways.

    • Paris Roidos
    • Stephanie Sungalee
    • Balca R. Mardin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The discovery of a human lower jaw associated with stone tools and animal bones from the Sima del Elefante in northern Spain is reported. The finds have been dated to between 1.1 and 1.2 million years using a variety of dating techniques, making the site the oldest and most accurately dated record of human occupation in Europe.

    • Eudald Carbonell
    • José M. Bermúdez de Castro
    • Juan L. Arsuaga
    Research
    Nature
    Volume: 452, P: 465-469

  • Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

    • Bin Zhou
    • Kate E. Sheffer
    • Majid Ezzati
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 2885-2901

  • Two different methylation states of the adenosine adjacent to the snRNA cap are found in the biogenesis process of snRNAs, Am and m6Am, whose levels are regulated by FTO and are related to alternative pre-mRNA splicing.

    • Jan Mauer
    • Miriam Sindelar
    • Samie R. Jaffrey
    Research
    Nature Chemical Biology
    Volume: 15, P: 340-347

  • Fat mass and obesity-associated protein (FTO) preferentially demethylates m6Am, a modified adenosine that, when present at the 5′ end of certain mRNAs, positively influences mRNA stability by preventing DCP2-mediated decapping.

    • Jan Mauer
    • Xiaobing Luo
    • Samie R. Jaffrey
    Research
    Nature
    Volume: 541, P: 371-375

  • Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflammation and CAC progression.

    • Claudia M. Wunderlich
    • P. Justus Ackermann
    • F. Thomas Wunderlich
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • A number of clinical studies have demonstrated that patients with high-risk squamous-cell carcinoma of the head and neck benefit from the addition of EGFR inhibitors to chemotherapy and radiotherapy. The rationale for using targeted therapies based on inhibition of EGFR and angiogenesis, and the most recent pre–clinical and clinical evidence for the role of these agents in the management of head and neck cancers is discussed.

    • Jacques Bernier
    • Søren M. Bentzen
    • Jan B. Vermorken
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 6, P: 266-277

  • A water harvesting strategy utilizing a hygroscopic lithium chloride impregnated cellulose scaffold yields high water harvesting rate with low energy input over a wide range of relative humidity. The strategy, reported by Wenkai Zhu, Yun Zhang, Chi Zhang and coworkers, provides a potential solution to the global water scarcity problem particularly in arid areas.

    • Wenkai Zhu
    • Yun Zhang
    • Tian Li
    ResearchOpen Access
    Communications Engineering
    Volume: 2, P: 1-10