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Advanced filters: Author: Jan Pankrac Clear advanced filters

  • MCL1 is an anti-apoptotic protein associated with cancer and therapy resistance. Here, the authors show that MCL1 regulates mTORC1 signalling and metabolism, explaining MCL1-inhibition reported cardiotoxicity, which can be mitigated by dietary leucine supplementation.

    • Wentao Gui
    • Petr Paral
    • Mohamed Elgendy
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20