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Showing 1–7 of 7 results
Advanced filters: Author: Jan Steensels Clear advanced filters

  • Site-specific recombinases such as the Cre-LoxP system are routinely used for genome engineering in both prokaryotes and eukaryotes. Here the authors develop 63 symmetrical LoxP variants and test 1192 pairwise combinations to determine their cross-reactivity and specificity upon Cre activation.

    • Charlotte Cautereels
    • Jolien Smets
    • Kevin J. Verstrepen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • In this Review, Steensels, Gallone and Verstrepen discuss the origin and evolution of fungal interspecific hybrids and provide examples of how hybridization produced useful hybrids for industrial fermentations but also resulted in the emergence of highly virulent pathogens.

    • Jan Steensels
    • Brigida Gallone
    • Kevin J. Verstrepen
    Reviews
    Nature Reviews Microbiology
    Volume: 19, P: 485-500

  • Genomes and phenotypes of interspecific yeast hybrids isolated from breweries reveal hybridization between Saccharomyces species followed by adaptation to specific beer styles.

    • Brigida Gallone
    • Jan Steensels
    • Kevin J. Verstrepen
    Research
    Nature Ecology & Evolution
    Volume: 3, P: 1562-1575

  • In vivo mutagenesis allows improving cell factories through directed evolution. Here, the authors present CoMuTER, a tool for targetable random mutagenesis of complete biosynthetic pathways using a Cas3 enzyme fused to a cytidine deaminase.

    • Anna Zimmermann
    • Julian E. Prieto-Vivas
    • Kevin J. Verstrepen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of proteins, a process vital to organismal fitness. Here the authors show that the number of repeats in the polyubiquitin gene is evolutionarily unstable within and between yeast species, and that this variability may tune the cell’s capacity to respond to sudden environmental perturbations.

    • Rita Gemayel
    • Yudi Yang
    • Kevin J. Verstrepen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9