Nature Search

Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells

Roger Miesfeld
Sam Okret
Keith R. Yamamoto
Research20 Dec 1984
Nature

Volume: 312, P: 779-781
Solution structure of a mammalian PCB-binding protein in complex with a PCB

Torleif Härd
Henry J. Barnes
Johan Lund
Research01 Nov 1995
Nature Structural Biology

Volume: 2, P: 983-989
Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones

Lena Haglund
Christer Köhler
Jan-Åke Gustafsson
Research19 Jan 1984
Nature

Volume: 307, P: 259-262
Liver X receptor unlinks intestinal regeneration and tumorigenesis

Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

Srustidhar Das
S. Martina Parigi
Eduardo J. Villablanca
ResearchOpen Access20 Nov 2024
Nature

Volume: 637, P: 1198-1206
Not enough evidence to include ESR1 amplification

Christoforos Thomas
Jan-Åke Gustafsson
Correspondence24 Oct 2011
Nature Reviews Cancer

Volume: 11, P: 823
Estrogen receptor β — Getting in on the action?

Recent findings in mice hint that ERβ and not ERα may mediate some of the cardiovascular benefits of estrogen (pages 545–548).

Jan-Åke Gustafsson
News & Views01 May 1997
Nature Medicine

Volume: 3, P: 493-494
Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue

Brown adipose tissue (BAT) is key for metabolic balance. Here, the authors show that RAP250 deficiency enhances BAT activity. Under these conditions, BAT-derived neuritin-1 regulates thermogenesis and fat metabolism, showing therapeutic promise for obesity and metabolic disorders.

Manuela Sánchez-Feutrie
Montserrat Romero
Antonio Zorzano
ResearchOpen Access04 Sept 2025
Nature Communications

Volume: 16, P: 1-18
Raloxifene: Magic bullet for heart and bone?

Clinical results show that raloxifene benefits heart and bone in postmenopausal women without increasing the risk of uterine cancer but its long-term effects are unknown.

Jan-ÅKe Gustafsson
News & Views01 Feb 1998
Nature Medicine

Volume: 4, P: 152-153
Liver X receptor regulates Th17 and RORγt⁺ Treg cells by distinct mechanisms

Sara M. Parigi
Srustidhar Das
Eduardo J. Villablanca
Research17 Jul 2020
Mucosal Immunology

Volume: 14, P: 411-419
Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception

Sergi Soriano
Minerva Gil-Rivera
Juan Martinez-Pinna
ResearchOpen Access16 Jul 2019
Scientific Reports

Volume: 9, P: 1-14
Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca²⁺ entry in mouse pancreatic β-cells

Sabrina Villar-Pazos
Juan Martinez-Pinna
Angel Nadal
ResearchOpen Access18 Sept 2017
Scientific Reports

Volume: 7, P: 1-15
A CUE hints at tumor resistance

Some individuals with estrogen receptor–α (ER-α)-positive breast cancer do not respond to tamoxifen treatment. Increased expression of the ubiquitin ligase CUEDC2 may contribute to this endocrine resistance by reducing theamounts of ER-α (pages 708–714).

Christoforos Thomas
Jan-Ake Gustafsson
News & Views06 Jun 2011
Nature Medicine

Volume: 17, P: 658-660
Molecular and functional heterogeneity of IL-10-producing CD4⁺ T cells

Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD.

Leonie Brockmann
Shiwa Soukou
Samuel Huber
ResearchOpen Access21 Dec 2018
Nature Communications

Volume: 9, P: 1-14
Molecular basis of agonism and antagonism in the oestrogen receptor

Andrzej M. Brzozowski
Ashley C. W. Pike
Mats Carlquist
Research16 Oct 1997
Nature

Volume: 389, P: 753-758
The different roles of ER subtypes in cancer biology and therapy

Perturbation of oestrogen receptor (ER) subtype-specific expression has been detected in various types of cancer, and these differences correlate with the clinical outcome. The selective restoration or ablation of their activity is one of the major therapeutic approaches for hormone-dependent cancers.

Christoforos Thomas
Jan-Åke Gustafsson
Reviews22 Jul 2011
Nature Reviews Cancer

Volume: 11, P: 597-608
Principles for modulation of the nuclear receptor superfamily

Hinrich Gronemeyer
Jan-Åke Gustafsson
Vincent Laudet
Reviews01 Nov 2004
Nature Reviews Drug Discovery

Volume: 3, P: 950-964
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

Cholic acid and 24(S),25-epoxycholesterol are endogenous midbrain LXR ligands that are neurogenic for red nucleus or dopaminergic neurons, respectively.

Spyridon Theofilopoulos
Yuqin Wang
Ernest Arenas
Research23 Dec 2012
Nature Chemical Biology

Volume: 9, P: 126-133
Development of subtype-selective oestrogen receptor-based therapeutics

Classical selective oestrogen receptor modulators are well established in the treatment of breast cancer and osteoporosis, but emerging knowledge on the oestrogen receptor subtypes α and β suggests that subtype-selective modulators may hold promise for more efficacious and safer treatments of many other diseases and symptoms.

Stefan Nilsson
Konrad F. Koehler
Jan-Åke Gustafsson
Reviews16 Sept 2011
Nature Reviews Drug Discovery

Volume: 10, P: 778-792
An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice

Yi-fei Miao
Wen Su
Jan-Åke Gustafsson
ResearchOpen Access06 Dec 2016
Scientific Reports

Volume: 6, P: 1-11
Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA

The crystal structure of human RXRα–LXRβ heterodimer bound to its cognate DNA element, with agonists and a coactivator peptide, is now solved. The heterodimer shows an X-shaped organization, with DNA-binding and ligand-binding domains crossed, in contrast to previous crystal structures of nuclear receptor complexes.

Xiaohua Lou
Gudrun Toresson
Jan-Ake Gustafsson
Research23 Feb 2014
Nature Structural & Molecular Biology

Volume: 21, P: 277-281
Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

Sterol metabolism modulates immune responses through liver X receptor activation. Tumors harness this signaling pathway and can escape immunosurveillance by inhibiting dendritic cell migration to tumor-draining lymph nodes.

Eduardo J Villablanca
Laura Raccosta
Vincenzo Russo
Research27 Dec 2009
Nature Medicine

Volume: 16, P: 98-105
Role of LXRβ in oligodendrocytes in neuronal survival

Xiaoyu Song
Wanfu Wu
Margaret Warner
Research01 Oct 2025
Molecular Psychiatry

Volume: 31, P: 16-26
Expression of estrogen receptor β isoforms in normal breast epithelial cells and breast cancer: regulation by methylation

Chunyan Zhao
Eric W-F Lam
Karin Dahlman-Wright
Research23 Oct 2003
Oncogene

Volume: 22, P: 7600-7606
Targeting liver X receptors in cancer therapeutics

This Review discusses the roles of liver X receptors (LXRs) in cancer and the possibilities for targeting them.

Chin-Yo Lin
Jan-Åke Gustafsson
Reviews19 Mar 2015
Nature Reviews Cancer

Volume: 15, P: 216-224
Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

Hua Zhang
Sarita Panula
Kui Liu
Correspondence07 Oct 2015
Nature Medicine

Volume: 21, P: 1116-1118
High-Fat Diet Induces Unexpected Fatal Uterine Infections in Mice with aP2-Cre-mediated Deletion of Estrogen Receptor Alpha

Zsofia Ban
Paul Maurischat
Ulrich Kintscher
ResearchOpen Access24 Feb 2017
Scientific Reports

Volume: 7, P: 1-13
Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma

Gangadhara R. Sareddy
Xiaonan Li
Ratna K. Vadlamudi
ResearchOpen Access29 Apr 2016
Scientific Reports

Volume: 6, P: 1-13
Author Correction: Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca²⁺ entry in mouse pancreatic β-cells

Sabrina Villar-Pazos
Juan Martinez-Pinna
Angel Nadal
Amendments and CorrectionsOpen Access06 Mar 2018
Scientific Reports

Volume: 8, P: 1
The Hairy and Enhancer of Split homologue-1 (HES-1) mediates the proliferative effect of 17β-estradiol on breast cancer cell lines

Anders Ström
Naoya Arai
Jan-Åke Gustafsson
Research30 Nov 2000
Oncogene

Volume: 19, P: 5951-5953
Estrogen receptor β acts as a dominant regulator of estrogen signaling

Katarina Pettersson
Franck Delaunay
Jan-Åke Gustafsson
Research12 Oct 2000
Oncogene

Volume: 19, P: 4970-4978
Investigations of a CA repeat in the oestrogen receptor β gene in patients with Alzheimer's disease

Charlotte Forsell
Eva Enmark
Lars Lannfelt
Research19 Oct 2001
European Journal of Human Genetics

Volume: 9, P: 802-804
HES-1 inhibits 17β-estradiol and heregulin-β1-mediated upregulation of E2F-1

Johan Hartman
Patrick Müller
Anders Ström
Research04 Oct 2004
Oncogene

Volume: 23, P: 8826-8833
Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice

Xin Li
Hongyu Zhong
Xiaotang Fan
Research07 May 2021
Molecular Psychiatry

Volume: 26, P: 6380-6393
Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling

Kenichi Matsushita
Fulvio Morello
Victor J Dzau
Research23 Nov 2015
Laboratory Investigation

Volume: 96, P: 230-238
RETRACTED ARTICLE: BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1

Wenwen Zhang
Jiayan Luo
Xiaoxiang Guan
ResearchOpen Access23 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain

N Sugiyama
S Andersson
J-Å Gustafsson
Research04 Nov 2008
Molecular Psychiatry

Volume: 14, P: 223-232
Estrogen receptors alfa (ERα) and beta (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11

Luisa A Helguero
Malin Hedengran Faulds
Lars-Arne Haldosén
Research20 Jun 2005
Oncogene

Volume: 24, P: 6605-6616

Search

Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells

Solution structure of a mammalian PCB-binding protein in complex with a PCB

Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones

Liver X receptor unlinks intestinal regeneration and tumorigenesis

Not enough evidence to include ESR1 amplification

Estrogen receptor β — Getting in on the action?

Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue

Raloxifene: Magic bullet for heart and bone?

Liver X receptor regulates Th17 and RORγt⁺ Treg cells by distinct mechanisms

Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception

Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca²⁺ entry in mouse pancreatic β-cells

A CUE hints at tumor resistance

Molecular and functional heterogeneity of IL-10-producing CD4⁺ T cells

Molecular basis of agonism and antagonism in the oestrogen receptor

The different roles of ER subtypes in cancer biology and therapy

Principles for modulation of the nuclear receptor superfamily

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

Development of subtype-selective oestrogen receptor-based therapeutics

An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice

Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA

Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

Role of LXRβ in oligodendrocytes in neuronal survival

Expression of estrogen receptor β isoforms in normal breast epithelial cells and breast cancer: regulation by methylation

Targeting liver X receptors in cancer therapeutics

Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

High-Fat Diet Induces Unexpected Fatal Uterine Infections in Mice with aP2-Cre-mediated Deletion of Estrogen Receptor Alpha

Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma

Author Correction: Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca²⁺ entry in mouse pancreatic β-cells

The Hairy and Enhancer of Split homologue-1 (HES-1) mediates the proliferative effect of 17β-estradiol on breast cancer cell lines

Estrogen receptor β acts as a dominant regulator of estrogen signaling

Investigations of a CA repeat in the oestrogen receptor β gene in patients with Alzheimer's disease

HES-1 inhibits 17β-estradiol and heregulin-β1-mediated upregulation of E2F-1

Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice

Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling

RETRACTED ARTICLE: BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1

Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain

Estrogen receptors alfa (ERα) and beta (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11

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