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Showing 1–6 of 6 results
Advanced filters: Author: Janane F. Rahbani Clear advanced filters

  • Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown adipose tissue is, in addition to UCP1, also mediated by a UCP1-independent pathway, called the Futile Creatine Cycle

    • Jakub Bunk
    • Mohammed F. Hussain
    • Lawrence Kazak
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Tissue nonspecific alkaline phosphatase (TNAP) within mitochondria hydrolyses phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation in thermogenic fat cells.

    • Yizhi Sun
    • Janane F. Rahbani
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 593, P: 580-585

  • Assembling defined sequences of DNA is important for many applications, but the synthesis becomes more difficult as the target size increases. Here, the authors report a method for assembling DNA by combining smaller strands, with the final structure determined by the order of addition of the fragments.

    • Graham D. Hamblin
    • Janane F. Rahbani
    • Hanadi F. Sleiman
    Research
    Nature Communications
    Volume: 6, P: 1-8

  • Creatine can be used for thermogenesis in adipocytes. Here Kazak et al. show that creatine uptake is required to sustain this thermogenic pathway. Knockdown of the creatine transporter, CrT, in adipocytes decreases thermogenesis and energy expenditure, whereas creatine supplementation increases energy expenditure in mice fed a high-fat diet.

    • Lawrence Kazak
    • Janane F. Rahbani
    • Bruce M. Spiegelman
    Research
    Nature Metabolism
    Volume: 1, P: 360-370