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Showing 51–100 of 296 results
Advanced filters: Author: Jane Alfred Clear advanced filters

  • Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

    • David W Clark
    • Yukinori Okada
    • James F Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

    • Mark Patterson PhD
    • Jane Alfred PhD
    • Tanita Casci PhD
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 155

  • Multi-proxy core data and model simulations support the presence of temperate rainforests near the South Pole during mid-Cretaceous warmth, indicating very high CO2 levels and the absence of Antarctic ice.

    • Johann P. Klages
    • Ulrich Salzmann
    • M. Scheinert
    Research
    Nature
    Volume: 580, P: 81-86

    • Jane Wess
    Comments & Opinion
    Nature Physics
    Volume: 2, P: 644

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 231

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 399

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 733

    • Jane Alfred
    • Tanita Casci
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 727

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 483

    • Jane Alfred
    • Tanita Casci
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 569

  • The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that SNX9 knockout is associated with improved T cell function and anti-tumor activity in preclinical cancer models.

    • Marcel P. Trefny
    • Nicole Kirchhammer
    • Alfred Zippelius
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Previous work has identified several genes where mutations lead to breast cancer, but other genetic and environmental factors must still be accounted for. A large study of genetic association with breast cancer points to four novel genes and many more genetic markers that should be pursued for their link to cancer susceptibility.

    • Douglas F. Easton
    • Karen A. Pooley
    • Bruce A. J. Ponder
    Research
    Nature
    Volume: 447, P: 1087-1093

  • A translational study demonstrates the role of myeloid inflammatory cells in driving disease progression and treatment resistance in prostate cancer and shows that these cells can be targeted therapeutically.

    • Christina Guo
    • Adam Sharp
    • Johann S. de Bono
    ResearchOpen Access
    Nature
    Volume: 623, P: 1053-1061

  • In a phase II, randomized, placebo-controlled, double-blind cross-over trial, Jama et al. show that delivery of short-chain fatty acids via acetylated and butyrylated high-amylose maize starch (HAMSAB) supplementation result in a clinically relevant reduction in 24-hour systolic blood pressure in patients with essential hypertension.

    • Hamdi A. Jama
    • Dakota Rhys-Jones
    • Francine Z. Marques
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 35-43

  • Cutaneous gamma-delta T cell lymphomas are rare but aggressive cancers. Here, by DNA, RNA and T cell receptor sequencing, the authors elucidate the molecular ontogeny by revising the cell of origin and identifying potentially targetable mutations.

    • Jay Daniels
    • Peter G. Doukas
    • Jaehyuk Choi
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

    • Jane Alfred
    • Tanita Casci
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 319

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 563

    • Mark Patterson PhD
    • Jane Alfred PhD
    • Tanita Casci PhD
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 1

    • Jane Alfred
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 490

    • Mark Patterson PhD
    • Jane Alfred PhD
    • Tanita Casci PhD
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 81

    • Jane Alfred
    • Tanita Casci
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 489

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 81

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 825

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 323

    • Jane Alfred
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 646

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 909

    • Mark Patterson
    • Jane Alfred
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 2, P: 649

    • Jane Alfred
    Research Highlights
    Nature Reviews Genetics
    Volume: 1, P: 7

    • Jane Alfred
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 820

    • Jane Alfred
    • Tanita Casci
    • Magdalena Skipper
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 405

    • Jane Alfred
    Research Highlights
    Nature Reviews Genetics
    Volume: 3, P: 324

    • Jane Alfred
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 3, P: 637