Nature Search

Seal echolocation?

DOUGLAS WARTZOK
RONALD J. SCHUSTERMAN
JANET GAILEY-PHIPPS
Research19 Apr 1984
Nature

Volume: 308, P: 753
Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis

Gangliosides are bioactive lipids important for neuronal cell function. Here, authors reveal the dynamic structure of the ganglioside synthetic enzyme B4GALNT1 and demonstrate how it inserts into membranes to access and process lipid substrates.

Jack W. J. Welland
Henry G. Barrow
Janet E. Deane
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

Although the precise function of Tryptophan rich antigen multi-gene family (TRAgs) proteins is not known in any Plasmodium species several members of the P. vivax TRAg family have been reported to have red blood cell binding properties. Here, Kundu and Naskar et al. provide the X-ray crystallography structure of a P. vivax TRAg domain of PVP01_0000100. Structural and biochemical assays suggest a lipid binding function for a pan-Plasmodium multi-gene family.

Prasun Kundu
Deboki Naskar
Julian C. Rayner
ResearchOpen Access14 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Zika viruses encode 5′ upstream open reading frames affecting infection of human brain cells

Here the authors identify upstream open reading frames (uORFs), uORF1 and uORF2 in the Asian/American lineage and African uORF in the African lineage of Zika viruses, and show that uORF1 affects vimentin filaments and that the identified uORFs affect virus replication in neural cells.

Charlotte Lefèvre
Georgia M. Cook
Nerea Irigoyen
ResearchOpen Access12 Oct 2024
Nature Communications

Volume: 15, P: 1-19
The receptor PTPRU is a redox sensitive pseudophosphatase

Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may act as a decoy receptor for substrate sequestration.

Iain M. Hay
Gareth W. Fearnley
Janet E. Deane
ResearchOpen Access26 Jun 2020
Nature Communications

Volume: 11, P: 1-13
An in vivo platform to select and evolve aggregation-resistant proteins

Protein aggregation remains a significant challenge for manufacturing of protein biopharmaceuticals. Here, the authors demonstrate the use of directed evolution and an assay for in vivo innate protein aggregation-propensity to generate aggregation-resistant scFv fragments.

Jessica S. Ebo
Janet C. Saunders
David J. Brockwell
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-12
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

Hunter syndrome is a lysosomal storage disease caused by mutations in the enzyme iduronate-2-sulfatase (IDS). Here, the authors present the IDS crystal structure and give mechanistic insights into mutations that cause Hunter syndrome.

Mykhaylo Demydchuk
Chris H. Hill
Randy J. Read
ResearchOpen Access08 Jun 2017
Nature Communications

Volume: 8, P: 1-9
Architecture of the major component of the type III secretion system export apparatus

The transmembrane export apparatus regulates protein secretion through bacterial type III secretion systems. New structural data indicate that MxiA, a major component of the apparatus, assembles in a nonameric ring. This and additional structural information provide a framework for understanding how protein secretion is controlled.

Patrizia Abrusci
Marta Vergara-Irigaray
Susan M Lea
Research09 Dec 2012
Nature Structural & Molecular Biology

Volume: 20, P: 99-104
The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure

Lysosomal degradation of sphingolipids requires lipid-binding saposin proteins and hydrolytic enzymes. Here the authors present the crystal structure of the hydrolase β-galactocerebrosidase in complex with saposin SapA and give insights into the glycosphingolipid galactocerebroside degradation mechanism.

Chris H. Hill
Georgia M. Cook
Janet E. Deane
ResearchOpen Access11 Jan 2018
Nature Communications

Volume: 9, P: 1-9
Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

Neisseria meningitidis possesses a surface protein called fHbp that binds to the complement regulator factor H, thereby interfering with the host immune response. Now the structure of N. meningitidis fHbp bound to factor H is presented, revealing the molecular interactions between these two molecules.

Muriel C. Schneider
Beverly E. Prosser
Susan M. Lea
Research18 Feb 2009
Nature

Volume: 458, P: 890-893
A structural biology community assessment of AlphaFold2 applications

Here, the authors evaluate the performance of AlphaFold2 and its predicted structures on common structural biological applications, including missense variants, function and ligand binding site prediction, modeling of interactions and modeling of experimental structural data.

Mehmet Akdel
Douglas E. V. Pires
Pedro Beltrao
ResearchOpen Access07 Nov 2022
Nature Structural & Molecular Biology

Volume: 29, P: 1056-1067
Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Genome-wide association studies have identified regions which confer risk of high-grade serous epithelial ovarian cancer. Here the authors use expression quantitative train locus analysis to identify candidate genes and functionally characterise them, identifying a role for HOXD9 in ovarian cancer.

Kate Lawrenson
Qiyuan Li
Matthew L. Freedman
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-14
Explaining trunk strength variation and improvement following resistance training in people with chronic low back pain: clinical and performance-based outcomes analysis

Shouq Althobaiti
David Jiménez‑Grande
Deborah Falla
ResearchOpen Access13 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
Facile preparation of flame-retardant cellulose composite with biodegradable and water resistant properties for electronic device applications

Saravanan Chandrasekaran
Alvaro Cruz-Izquierdo
Janet L. Scott
ResearchOpen Access23 Feb 2023
Scientific Reports

Volume: 13, P: 1-12
Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes

Bojidar Rangelov
Alexandra Young
Mark Radon
ResearchOpen Access20 Jun 2023
Scientific Reports

Volume: 13, P: 1-14
Author Correction: Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes

Bojidar Rangelov
Alexandra Young
Mark Radon
Amendments and CorrectionsOpen Access26 Oct 2023
Scientific Reports

Volume: 13, P: 1

Search

Seal echolocation?

Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis

The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Zika viruses encode 5′ upstream open reading frames affecting infection of human brain cells

The receptor PTPRU is a redox sensitive pseudophosphatase

An in vivo platform to select and evolve aggregation-resistant proteins

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

Architecture of the major component of the type III secretion system export apparatus

The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

A structural biology community assessment of AlphaFold2 applications

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Explaining trunk strength variation and improvement following resistance training in people with chronic low back pain: clinical and performance-based outcomes analysis

Facile preparation of flame-retardant cellulose composite with biodegradable and water resistant properties for electronic device applications

Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes

Author Correction: Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes

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