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Showing 1–6 of 6 results
Advanced filters: Author: Janet Finer-Moore Clear advanced filters

  • In Gram-negative bacterial outer membranes, lipid A serves as the anchor for lipopolysaccharide. Structural and biochemical data reveal that LpxI, an enzyme involved in lipid A synthesis, uses a hinge-like mechanism to deposit its product into the membrane through the binding of fresh substrate.

    • Louis E Metzger IV
    • John K Lee
    • Robert M Stroud
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1132-1138

  • Polyketide synthase 13 from mycobacteria was purified endogenously ‘in action’ with wild-type substrates bound. Structures by cryo-EM define multiple states of acyl carrier proteins in the final step of mycolic acid synthesis by a key drug target.

    • Sun Kyung Kim
    • Miles Sasha Dickinson
    • Robert M. Stroud
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 296-308

  • Accumulation of misfolded proteins results in the activation of the unfolded protein response (UPR) in the endoplasmic reticulum. Ire1 is important in this pathway and functions as a kinase and endoribonuclease. This paper solves the crystal structure of Ire1 kinase and shows that it undergoes spontaneous assembly into a rod-shaped oligomer. This arrangement positions the kinase domains for trans-autophosphorylation, orders the RNase domains and creates an interaction site for mRNA substrate binding.

    • Alexei V. Korennykh
    • Pascal F. Egea
    • Peter Walter
    Research
    Nature
    Volume: 457, P: 687-693