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Showing 1–9 of 9 results
Advanced filters: Author: Janet H. Iwasa Clear advanced filters

  • Poly-ADP-ribose polymerase 1 (PARP1) plays key roles in DNA repair, transcription, and replication. Here, the authors used a single-molecule approach to reveal how PARP1 identifies DNA single-strand breaks in nucleosomes and how PARP1 activity regulates its DNA and chromatin binding kinetics.

    • Matthew A. Schaich
    • Tyler M. Weaver
    • Bennett Van Houten
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-16

  • Water thermodynamics drive changes in macromolecular assembly that rapidly restore intracellular water availability in response to physiological fluctuations in temperature, pressure and osmotic strength.

    • Joseph L. Watson
    • Estere Seinkmane
    • Emmanuel Derivery
    ResearchOpen Access
    Nature
    Volume: 623, P: 842-852

  • Microsporidia are obligate intracellular parasitic fungi that can cause opportunistic infections in humans. Here, Antao et al. investigate the intracellular life cycle of human-infecting Encephalitozoon intestinalis using serial block-face scanning electron microscopy to characterize parasite organelle development and host-cell mitochondrial remodeling.

    • Noelle V. Antao
    • Cherry Lam
    • Gira Bhabha
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Cryo-EM structures of human ESCRT-III proteins forming membrane-bound and membrane-free filaments show how CHMP1B and IST1 polymerize sequentially, driving membrane tubulation, constriction and bilayer thinning, leading to membrane fission.

    • Henry C. Nguyen
    • Nathaniel Talledge
    • Adam Frost
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 392-399

  • Here, the authors comprehensively discuss the different mechanisms for origin licensing in yeast and human cells. Importantly, they present intuitive videos illustrating such mechanisms with unprecedented detail.

    • Bruce Stillman
    • John F. X. Diffley
    • Janet H. Iwasa
    Reviews
    Nature Structural & Molecular Biology
    Volume: 32, P: 1143-1153

  • Interactive annotation and commenting tools provide a means to ground animations in experimental evidence and to support scientific discourse and progress.

    • Janet H. Iwasa
    Comments & Opinion
    Nature Microbiology
    Volume: 7, P: 3

  • New observations of ESCRT-mediated reverse-topology membrane scission are building towards a structural and biophysical explanation of the mechanism involved.

    • Johannes Schöneberg
    • Il-Hyung Lee
    • James H. Hurley
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 5-17

  • The Mediator complex is an important regulator of RNA polymerase II. This Review discusses recent structural insights into Mediator function and proposes a model that reconciles contradictory data on whether enhancer–promoter communication during transcription is direct or indirect.

    • William F. Richter
    • Shraddha Nayak
    • Dylan J. Taatjes
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 732-749