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Showing 1–11 of 11 results
Advanced filters: Author: Janet Sanford Clear advanced filters

  • Semantic heterogeneity exists regarding terminology for active surveillance (AS) for prostate cancer. A panel of leading specialists in prostate cancer and AS involved in the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) consortium participated in a consensus-forming project to reach international consensus on definitions of terms related to this management option. This standard terminology could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.

    • Sophie M. Bruinsma
    • Monique J. Roobol
    • Sophie Bruinsma
    ReviewsOpen Access
    Nature Reviews Urology
    Volume: 14, P: 312-322

  • Medulloblastomas are the most common malignant childhood brain tumours and are thought to arise from the cerebellum. There is substantial heterogeneity among medulloblastomas and some are thought to arise following aberrant Sonic Hedgehog pathway activation. It is now shown that a distinct subtype of medulloblastoma arises from the dorsal brainstem and is associated with altered WNT signalling. Distinct molecular and clinical profiles of the subtypes have implications for future treatment.

    • Paul Gibson
    • Yiai Tong
    • Richard J. Gilbertson
    Research
    Nature
    Volume: 468, P: 1095-1099

  • How MICL recognizes and autoregulates the formation of neutrophil extracellular traps is explored in mouse models and human patients where disease severity is associated with aberrant neutrophil extracellular trap formation.

    • Mariano Malamud
    • Lauren Whitehead
    • Gordon D. Brown
    ResearchOpen Access
    Nature
    Volume: 633, P: 442-450

  • Medulloblastoma is the most common malignant brain tumour in children; having assembled over 1,000 samples the authors report that somatic copy number aberrations are common in medulloblastoma, in particular a tandem duplication of SNCAIP, a gene associated with Parkinson’s disease, which is restricted to subgroup 4α, and translocations of PVT1, which are restricted to Group 3.

    • Paul A. Northcott
    • David J. H. Shih
    • Michael D. Taylor
    ResearchOpen Access
    Nature
    Volume: 488, P: 49-56

  • To address the question of whether a recurrent tumour is genetically similar to the tumour at diagnosis, the evolution of medulloblastoma has been studied in both an in vivo mouse model of clinical tumour therapy as well as in humans with recurrent disease; targeted tumour therapies are usually based on targets present in the tumour at diagnosis but the results from this study indicate that post-treatment recurring tumours (compared with the tumour at diagnosis) have undergone substantial clonal divergence of the initial dominant tumour clone.

    • A. Sorana Morrissy
    • Livia Garzia
    • Michael D. Taylor
    Research
    Nature
    Volume: 529, P: 351-357