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Nature Microbiology (2)
Scientific Reports (1)

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Showing 1–3 of 3 results

Advanced filters: Author: Janina Deutschmann Clear advanced filters

A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1

SAMHD1 inhibits murine cytomegalovirus replication in vivo and its activity is counteracted by the viral kinase M97. Phosphorylation of SAMHD1 by M97 correlates with reduced dNTP hydrolase activity and a loss of viral restriction in infected cells.

Janina Deutschmann
Andrea Schneider
Thomas Gramberg
Research23 Sept 2019
Nature Microbiology

Volume: 4, P: 2273-2284
Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97

Human cytomegalovirus antagonizes the antiviral activity of sterile alpha motif and histidine–aspartate domain-containing protein 1 (SAMHD1) in macrophages by deploying the viral kinase pUL97 and hijacking cellular kinases.

Ramona Businger
Janina Deutschmann
Michael Schindler
Research23 Sept 2019
Nature Microbiology

Volume: 4, P: 2260-2272
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15