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Nature Cell Biology (2)
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Showing 1–3 of 3 results

Advanced filters: Author: Janine H. van Ree Clear advanced filters

Hyperphosphorylated PTEN exerts oncogenic properties

PTEN has tumor suppressive functions. Here the authors report that PTEN C-tail hyperphosphorylation promotes neoplastic growth through oncogenic activation of WNT signalling.

Janine H. van Ree
Karthik B. Jeganathan
Jan M. van Deursen
ResearchOpen Access24 May 2023
Nature Communications

Volume: 14, P: 1-17
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

The amount of the BubR1 checkpoint protein declines with age in mouse models, suggesting that it has a role in ageing. Van Deursen and colleagues reveal that expressing a BubR1 transgene in mice reduces tumorigenesis and aneuploidy, and delays ageing-related phenotypes.

Darren J. Baker
Meelad M. Dawlaty
Jan M. van Deursen
Research16 Dec 2012
Nature Cell Biology

Volume: 15, P: 96-102
Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

By engineering mice to express a version of the Pten tumour suppressor that lacks the three C-terminal amino acids, van Deursen and colleagues reveal a role for the protein in the generation of symmetric spindles through recruitment of Eg5 to centrosomes.

Janine H. van Ree
Hyun-Ja Nam
Jan M. van Deursen
Research30 May 2016
Nature Cell Biology

Volume: 18, P: 814-821