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Showing 1–25 of 25 results
Advanced filters: Author: Janis A Müller Clear advanced filters

  • Spectroscopic studies and theoretical calculations of the electrocatalytic oxygen evolution reaction establish that reaction rates depend on the amount of charge stored in the electrocatalyst, and not on the applied potential.

    • Hong Nhan Nong
    • Lorenz J. Falling
    • Travis E. Jones
    Research
    Nature
    Volume: 587, P: 408-413

  • The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, but its spike protein doesn’t efficiently bind human ACE2. Here, the authors show that exchange of spike residue 403 between RaTG13 and SARS-CoV-2 spike proteins affects binding to human ACE2 and entry of pseudotyped viruses.

    • Fabian Zech
    • Daniel Schniertshauer
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • In this prospective cohort study, authors follow 328 households in Germany with at least one confirmed SARS-CoV-2 infection and find that children are more likely to seroconvert without symptoms and have higher specific antibody levels that persist longer than in adults.

    • Hanna Renk
    • Alex Dulovic
    • Roland Elling
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Semen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses.

    • Janis A. Müller
    • Mirja Harms
    • Jan Münch
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

    • Vassily Trubetskoy
    • Antonio F. Pardiñas
    • Jim van Os
    Research
    Nature
    Volume: 604, P: 502-508

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

    • Lucia Trastulla
    • Georgii Dolgalev
    • Michael J. Ziller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-28

  • Semen-derived peptides can form amyloid fibrils that boost HIV infection in vitro, but the existence of such fibrils in semen remained to be demonstrated. Here, the authors show that human semen contains amyloid fibrils, which can bind HIV particles and increase their infectiveness.

    • Shariq M. Usmani
    • Onofrio Zirafi
    • Jan Münch
    Research
    Nature Communications
    Volume: 5, P: 1-8

  • Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.

    • Lukas Wettstein
    • Tatjana Weil
    • Jan Münch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entry.

    • Caterina Prelli Bozzo
    • Rayhane Nchioua
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

    • Nolan Kamitaki
    • Aswin Sekar
    • Steven A. McCarroll
    Research
    Nature
    Volume: 582, P: 577-581

  • The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

    • Barbara Franke
    • Jason L Stein
    • Patrick F Sullivan
    Research
    Nature Neuroscience
    Volume: 19, P: 420-431

  • Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

    • Russell L. McLaughlin
    • Dick Schijven
    • Michael C. O’Donovan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • In congenital neutropenia, myeloid-lineage differentiation in response to the cytokine G-CSF is defective. Julia Skokowa et al. now show that an interplay among three proteins—the adapter proteins HCLS1 and HAX1 and the transcription factor LEF-1—is required for G-CSF–triggered granulocytic differentiation, and they provide evidence that this pathway is dysregulated in both congenital neutropenia and acute myeloid leukemia.

    • Julia Skokowa
    • Maxim Klimiankou
    • Karl Welte
    Research
    Nature Medicine
    Volume: 18, P: 1550-1559

  • Schizophrenia is a highly heritable genetic disorder, however, identification of specific genetic risk variants has proven difficult because of its complex polygenic nature—a large multi-stage genome-wide association study identifies 128 independent associations in over 100 loci (83 of which are new); key findings include identification of genes involved in glutamergic neurotransmission and support for a link between the immune system and schizophrenia.

    • Stephan Ripke
    • Benjamin M. Neale
    • Michael C. O’Donovan
    Research
    Nature
    Volume: 511, P: 421-427

  • This study describes the development and characterization of peptidomimetic inhibitors of TMPRSS2, which primes the Spike protein of SARS-CoV-2. The inhibitors are shown to prevent SARS-CoV-2 infection in cells as efficiently as camostat mesylate.

    • Lukas Wettstein
    • Philip Maximilian Knaff
    • Volker Mailänder
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-12

  • Understanding the atomic dynamics of active catalyst sites is crucial for the precise optimization of catalyst performance. Here, the authors employ operando XAFS and DRIFTS to study the dynamics of the mobility of platinum and copper dopants in bimetallic and trimetallic gold nanoclusters supported on ceria, using the water-gas shift process as a model reaction.

    • Nicole Müller
    • Rareş Banu
    • Noelia Barrabés
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10

  • Analysis of the ability of Spike proteins from 26 human or animal coronaviruses (CoVs) to use ACE2 receptors across nine reservoir, potential intermediate, and human hosts reveals determinants of ACE2 receptor usage for diverse CoVs.

    • Qingxing Wang
    • Sabrina Noettger
    • Frank Kirchhoff
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-12