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Showing 1–5 of 5 results
Advanced filters: Author: Janki Shah Clear advanced filters

  • Microalbuminuria, a clinical marker associated with cancer and hypertension, defined by low albumin levels in the urine, is normally detected by immunoassay. Herein, a nanosensor paint was developed using a polymer to mimic fatty acid binding to albumin, transduced by carbon nanotube fluorescence.

    • Januka Budhathoki-Uprety
    • Janki Shah
    • Daniel A. Heller
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • A carbon nanotube-based sensor was developed to monitor endolysosomal acidification events in live cells and in vivo. The technology enables a spatiotemporal measurement of endolysosomal pH and real-time tracking of the dynamics of autophagy in tumors.

    • Mijin Kim
    • Chen Chen
    • Daniel A. Heller
    Research
    Nature Chemical Biology
    Volume: 19, P: 1448-1457

  • Head and neck squamous cell carcinomas (HNSCC) often harbourPIK3CAmutations but PI3Kα inhibitors can cause some side effects. Here, the authors develop P-selectin targeted nanoparticles to enhance tumour-specific delivery of a PI3Kα inhibitor to HNSCC PDX and orthotopic xenograft models.

    • Aviram Mizrachi
    • Yosi Shamay
    • Maurizio Scaltriti
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Molecular simulations reveal the self-assembly of small molecules into nanoparticle drug carriers. Targeting of colon and liver cancer cells by the nanoparticles via kinase inhibitors is employed in anti-tumour therapy in vivo.

    • Yosi Shamay
    • Janki Shah
    • Daniel A. Heller
    Research
    Nature Materials
    Volume: 17, P: 361-368