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Showing 1–5 of 5 results
Advanced filters: Author: Jannik Zimmermann Clear advanced filters

  • Head and neck squamous cell carcinoma (HNSCC) frequency and risk factors vary considerably across regions and ancestries. Here, the authors conduct a multi-ancestry genome-wide association study and fine mapping study of HNSCC subsites in cohorts from multiple continents, finding susceptibility and protective loci, gene-environment interactions, and gene variants related to immune response.

    • Elmira Ebrahimi
    • Apiwat Sangphukieo
    • Tom Dudding
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Glutaredoxins play a central role in numerous biological processes including cellular redox homeostasis and Fe-S cluster biogenesis. Here the authors establish the molecular basis for glutaredoxin redox catalysis through comprehensive biochemical and structural analyses.

    • Linda Liedgens
    • Jannik Zimmermann
    • Marcel Deponte
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • In ice-rich Siberian permafrost sediments deposited during the Pleistocene, 33-74% of the organic carbon is mineral-bound favoured by the presence of reactive iron, which can reduce microbial CO2 production after thawing

    • Jannik Martens
    • Carsten W. Mueller
    • Janet Rethemeyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • This article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell-cycle-linked NADP oscillations, and glutathione as the major conduit for anti-oxidative electron flux.

    • Marie Scherschel
    • Jan-Ole Niemeier
    • Bruce Morgan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Hydrogen peroxide and peroxiredoxin oxidation levels oscillate during the yeast metabolic cycle, while the absence of peroxiredoxins or the use of thiol oxidants and reductants disrupts metabolic cycling and its coupling with cell division.

    • Prince Saforo Amponsah
    • Galal Yahya
    • Bruce Morgan
    Research
    Nature Chemical Biology
    Volume: 17, P: 477-484