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Showing 1–3 of 3 results
Advanced filters: Author: Japheth E. Gado Clear advanced filters

  • Polyamides (PAs) or nylons are types of plastics with wide applications, but due to their accumulation in the environment, strategies for their deconstruction are of interest. Here, the authors screen 40 potential nylon-hydrolyzing enzymes (nylonases) using a mass spectrometry-based approach and identify a thermostabilized N-terminal nucleophile hydrolase as the most promising for further development, as well as crucial targets for progressing PA6 enzymatic depolymerization.

    • Elizabeth L. Bell
    • Gloria Rosetto
    • Gregg T. Beckham
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Accurately predicting the optimal pH level for enzyme activity is challenging due to the complex relationship between enzyme structure and function. Gado and colleagues show that a language model can effectively learn the structural and biophysical features to predict the optimal pH for enzyme activity.

    • Japheth E. Gado
    • Matthew Knotts
    • Gregg T. Beckham
    Research
    Nature Machine Intelligence
    Volume: 7, P: 716-729

  • Enzymes have potential for recycling plastics such as PET, a polyester used in textiles and single-use packaging. Here, the authors identify and characterize additional PET-active biocatalysts and expand the number and diversity of thermotolerant scaffolds for enzymatic PET deconstruction.

    • Erika Erickson
    • Japheth E. Gado
    • John E. McGeehan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15