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Showing 1–7 of 7 results
Advanced filters: Author: Jared Carlson-Stevermer Clear advanced filters

  • Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.

    • Jared Carlson-Stevermer
    • Reed Kelso
    • Travis Maures
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7

  • Gene editing strategies are typically designed to correct mutant genes, but most neurodegenerative diseases are sporadic. Here the authors describe a strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregulating neuroprotective α-cleavage.

    • Jichao Sun
    • Jared Carlson-Stevermer
    • Subhojit Roy
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Using a multi-OMICS approach, Haas et al identify 54 human genes and 16 host-targeting chemical compounds that regulate influenza A virus infection in lung epithelial cells, including AHNAK and COBP1 which are also essential for SARS-CoV-2 infection.

    • Kelsey M. Haas
    • Michael J. McGregor
    • Nevan J. Krogan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-27

  • Here, Mac Kain and Maarifi et al. perform a functional CRISPR/Cas9 screen to identify SARS-CoV-2 restriction factors in A549 cells. They identify DAXX, a scaffold protein of nuclear bodies with diverse functions, that has anti-viral activity post SARS-CoV-2 entry, while SARS-CoV-2 has evolved a mechanism to counteract its action via PLpro-mediated proteasomal degradation.

    • Alice Mac Kain
    • Ghizlane Maarifi
    • Ferdinand Roesch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Using CRISPR to write specific genetic sequences can sometimes be difficult due to the preference of mammalian cells to repair breaks using NHEJ. Here the authors form nanoparticles to localize the template sequence to the nuclease, shifting repair in favor of HDR.

    • Jared Carlson-Stevermer
    • Amr A. Abdeen
    • Krishanu Saha
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13