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Showing 1–7 of 7 results
Advanced filters: Author: Jared L. Piper Clear advanced filters

  • The oomycete Phytophthora infestans is a damaging crop pathogen. Here, the authors show that a group of P. infestans secreted enzymes play roles in penetration and colonization of host plants by oxidising fragments of the polysaccharide pectin in the plant cell wall.

    • Lydia R. J. Welsh
    • Anna O. Avrova
    • Federico Sabbadin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Acyl radicals represent a reactive species that allow for aldehyde subunits to be nucleophilic instead of their typical electrophilic behavior; however, these species are difficult to access in mild conditions. Here the authors show a method to generate acyl radicals using only an organic photocatalyst and light, and these species are shown as competent nucleophiles in a variety of couplings.

    • Jianming Yan
    • Haidi Tang
    • Jie Wu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Weitzner et al. describe a computational protocol that uses RosettaAntibody to predict antibody structures from sequence data. SnugDock is then used for docking of these structures to protein antigens.

    • Brian D Weitzner
    • Jeliazko R Jeliazkov
    • Jeffrey J Gray
    Protocols
    Nature Protocols
    Volume: 12, P: 401-416

  • Insecticide resistance (IR) poses a major global health challenge. Here, the authors generate common IR mutations in laboratory Drosophila strains and use a CRISPR-based allelic-drive to replace an IR allele with a susceptible wild-type counterpart, providing a potent new tool for vector control.

    • Bhagyashree Kaduskar
    • Raja Babu Singh Kushwah
    • Ethan Bier
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • Functionalization of C–H bonds through direct hydrogen atom transfer (HAT) photocatalysis is an attractive synthetic reaction; however, many methods suffer from low catalytic efficiency. Now, the efficiency of direct HAT photocatalysis using photocatalyst eosin Y combined with Brønsted acids is reported, enabling the functionalization of unactivated C(sp3)–H bonds.

    • Hui Cao
    • Degong Kong
    • Jie Wu
    Research
    Nature Synthesis
    Volume: 1, P: 794-803

  • Sustainable processes for the synthesis of new clinical candidates is a priority in pharmaceutical manufacturing. This study presents a web application to predict the likely efficiencies of proposed synthetic routes before their evaluation in the laboratory.

    • Alina Borovika
    • Jacob Albrecht
    • Martin D. Eastgate
    Research
    Nature Sustainability
    Volume: 2, P: 1034-1040