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Showing 1–5 of 5 results
Advanced filters: Author: Jasmin Svinka Clear advanced filters

  • Pflügler, Svinka et al. identify a subset of Paneth cells in mouse intestinal crypts and tumors, which express the immune checkpoint molecule Ido1 in a Stat1-dependent manner and promote tumor growth. Gene expression data from human colorectal cancer (CRC) suggest that a similar population is present in human cancer and opens the door for further studies of immune escape mechanisms in CRC.

    • Sandra Pflügler
    • Jasmin Svinka
    • Robert Eferl
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14

  • The mouse cancer model 'Multi-Hit' allows for the evaluation of oncogene cooperativities in tumor development based on stochastic Cre-recombination events. Cells with cooperating oncogenes are positively selected and give rise to tumors. The approach is used to study Ras downstream effector pathways in tumorigenesis.

    • Monica Musteanu
    • Leander Blaas
    • Robert Eferl
    Research
    Nature Methods
    Volume: 9, P: 897-900

  • STAT3 is an intracellular transducer of cytokine signals that cooperates with Ras in tumour formation and is often activated in lung cancer. Here the authors show that STAT3 acts as a tumour suppressor in a mouse model of Kras-driven lung adenocarcinoma.

    • Beatrice Grabner
    • Daniel Schramek
    • Emilio Casanova
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14