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Showing 1–2 of 2 results
Advanced filters: Author: Jason Alexander Halliwell Clear advanced filters

  • Mammalian oocytes and embryos undergo major epigenetic changes. Here, genome-wide mapping of the histone variant H2A.Z across mouse oogenesis and early embryogenesis reveals distinct maternal, embryonic and persistent enrichment patterns, linking histone variant dynamics to epigenetic inheritance, repeats and developmental reprogramming.

    • Madeleine Fosslie
    • Erkut Ilaslan
    • Mads Lerdrup
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • Here, the authors reveal the emerging replication timing program in mouse zygotes and 2-cell embryos, which differs from embryonic stem cells. They find systematic differences between the replication timing of the two parental genomes at pericentromeric regions and Polycomb target sites.

    • Jason Alexander Halliwell
    • Javier Martin-Gonzalez
    • Mads Lerdrup
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15