Nature Search

Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma

The activity of PD-1 blockade in patients with sarcoma has been modest so far. Here, the authors report the results of a pilot clinical trial to assess the efficacy and safety of bempegaldesleukin, a CD122-preferential interleukin-2 (IL-2) pathway agonist, in combination with the PD1 blockade (nivolumab) in patients with locally advanced or metastatic high-grade sarcoma.

Sandra P. D’Angelo
Allison L. Richards
William D. Tap
ResearchOpen Access16 Jun 2022
Nature Communications

Volume: 13, P: 1-11
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

Nikolay S. Markov
Ziyou Ren
Brian White
Research13 Aug 2024
Nature Immunology

Volume: 25, P: 1607-1622
The globalizability of temporal discounting

Ruggeri et al. find in a study of 61 countries that temporal discounting patterns are globally generalizable. Worse financial environments, greater inequality and high inflation are associated with extreme or inconsistent long-term decisions.

Kai Ruggeri
Amma Panin
Eduardo García-Garzon
ResearchOpen Access11 Jul 2022
Nature Human Behaviour

Volume: 6, P: 1386-1397
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets

Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequencing and find genomic groups that are distinct from histological subgroups.

Benjamin A. Nacev
Francisco Sanchez-Vega
William D. Tap
ResearchOpen Access15 Jun 2022
Nature Communications

Volume: 13, P: 1-15
Hardware-efficient quantum error correction via concatenated bosonic qubits

Bosonic qubits can be engineered to feature intrinsic protection against certain kinds of errors, which makes quantum error correction across many bosonic qubits possible with less overhead.

Harald Putterman
Kyungjoo Noh
Oskar Painter
ResearchOpen Access26 Feb 2025
Nature

Volume: 638, P: 927-934
Inequality in high-cost borrowing and unemployment insurance generosity in US states during the COVID-19 pandemic

Berger et al. use detailed credit data from the USA to examine the trade-off between government welfare support and consumer reliance on high-cost credit during the COVID-19 pandemic.

Lawrence M. Berger
Meta Brown
Alec P. Rhodes
Research11 Jul 2024
Nature Human Behaviour

Volume: 8, P: 1676-1688
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region.

Joanne M. Hildebrand
Maria Kauppi
John Silke
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-16
Myomaker is a membrane activator of myoblast fusion and muscle formation

A muscle-specific membrane protein called myomaker is transiently expressed during myogenesis and is both necessary and sufficient to drive myoblast fusion in vivo and in vitro.

Douglas P. Millay
Jason R. O’Rourke
Eric N. Olson
Research17 Jul 2013
Nature

Volume: 499, P: 301-305
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Analysis of bronchoalveolar lavage fluid samples from patients with SARS-CoV-2-induced respiratory failure suggests that SARS-CoV-2 infects alveolar macrophages to cause release of T cell chemoattractants, thereby inducing local inflammatory cytokine release and further T cell activation, ultimately resulting in a positive feedback loop that drives alveolar inflammation.

Rogan A. Grant
Luisa Morales-Nebreda
Ziyou Ren
Research11 Jan 2021
Nature

Volume: 590, P: 635-641
Precipitation impacts on earthen architecture for better implementation of cultural resource management in the US Southwest

Sharlot Hart
Kara Raymond
Matthew C. Guebard
ResearchOpen Access04 Nov 2021
Heritage Science

Volume: 9, P: 1-18
GPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin

Kathleen D. Triplett
Srijana Pokhrel
Pamela R. Hall
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer

Jason N Rosenbaum
Ryan Bloom
Eric J Duncavage
Research12 Jan 2018
Modern Pathology

Volume: 31, P: 791-808
Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function

Competition ChIP with a sequence-specific S. cerevisiae transcription factor, Rap1, reveals that long Rap1 residence is coupled to transcriptional activation, whereas fast binding turnover is linked to low transcriptional output, suggesting that DNA-binding events that appear identical by conventional ChIP may have different underlying modes of interaction, leading to opposing functional outcomes.

Colin R. Lickwar
Florian Mueller
Jason D. Lieb
Research11 Apr 2012
Nature

Volume: 484, P: 251-255
Indel variant analysis of short-read sequencing data with Scalpel

Fang et al. describe a computational protocol to accurately call indels from whole-genome and whole-exome sequencing data using Scalpel. Important issues for indel identification, such as short repeat regions and varying sequencing coverage, are discussed.

Han Fang
Ewa A Bergmann
Giuseppe Narzisi
Protocols17 Nov 2016
Nature Protocols

Volume: 11, P: 2529-2548
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952

Search

Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma

Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

The globalizability of temporal discounting

Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets

Hardware-efficient quantum error correction via concatenated bosonic qubits

Inequality in high-cost borrowing and unemployment insurance generosity in US states during the COVID-19 pandemic

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Myomaker is a membrane activator of myoblast fusion and muscle formation

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Precipitation impacts on earthen architecture for better implementation of cultural resource management in the US Southwest

GPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin

Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer

Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function

Indel variant analysis of short-read sequencing data with Scalpel

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Search

Quick links

Search

Filter By:

Search

Quick links