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Showing 1–9 of 9 results
Advanced filters: Author: Jason P. Briner Clear advanced filters

  • Alpine topography in Europe has been shaped by recent glaciations. Cosmogenic dating of summits in Svalbard suggest that Arctic alpine topography is a million years old and that subsequent glaciations have preserved rather than eroded the landscape.

    • Endre F. Gjermundsen
    • Jason P. Briner
    • Anne Hormes
    Research
    Nature Geoscience
    Volume: 8, P: 789-792

  • It emerges that ice discharge from a major ice sheet did not increase rapidly at the end of the most recent ice age. The finding points to steady, not catastrophic, ice-sheet loss and sea-level rise on millennial timescales. See Letter p.322

    • Jason P. Briner
    News & Views
    Nature
    Volume: 530, P: 287-288

  • Marine-terminating outlet glaciers control the stability of ice sheets. Exposure ages and radiocarbon dates show that an Arctic outlet glacier of the Laurentide ice sheet rapidly retreated about 9,500 years ago, and imply strong feedbacks between bathymetry and ice movement.

    • Jason P. Briner
    • Aaron C. Bini
    • Robert S. Anderson
    Research
    Nature Geoscience
    Volume: 2, P: 496-499

  • Fjords line mountainous continental margins where icesheets and glaciers once stood. A two-dimensional model simulation suggests that fjords can be eroded within one million years, primarily in response to topographic ice steering and erosion from ice discharge. Subsequent glaciers that form on these landscapes are smaller and exhibit greater responses to climate change.

    • Mark A. Kessler
    • Robert S. Anderson
    • Jason P. Briner
    Research
    Nature Geoscience
    Volume: 1, P: 365-369

  • Chapeau et al. develop a nonallosteric inhibitor of the interaction between YAP and all four TEAD proteins. Treatment with the inhibitor, either as monotherapy or in combination with other treatment modalities, leads to induction of cell death in several in vivo cancer models.

    • Emilie A. Chapeau
    • Laurent Sansregret
    • Tobias Schmelzle
    ResearchOpen Access
    Nature Cancer
    Volume: 5, P: 1102-1120

  • A high-throughput screen identified a small molecule that promoted inclusion of SMN2 exon 7, increased SMN2 protein levels and extended survival in a SMA mouse model through stabilization of the interaction between SMN2 pre-mRNA and U1 snRNP complex.

    • James Palacino
    • Susanne E Swalley
    • Rajeev Sivasankaran
    Research
    Nature Chemical Biology
    Volume: 11, P: 511-517

  • Measurements of cosmic-ray-produced 10Be and 26Al in a bedrock core from beneath the summit of the Greenland Ice Sheet show that Greenland was nearly ice-free for extended periods under Pleistocene climate forcing.

    • Joerg M. Schaefer
    • Robert C. Finkel
    • Roseanne Schwartz
    Research
    Nature
    Volume: 540, P: 252-255