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Showing 1–6 of 6 results
Advanced filters: Author: Jason Shu Lim Yu Clear advanced filters

  • Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

    • Jianxin Shi
    • Kouya Shiraishi
    • Qing Lan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • One common cause of vision loss after retinal detachment surgery is retinal scarring. Here the authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppression of epithelial-mesenchymal transition and hyper-proliferation of retinal pigment epithelial cells.

    • Bhav Harshad Parikh
    • Zengping Liu
    • Xinyi Su
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The harvest of large quantities of lysine by yeast and other microbes triggers a reprogramming of redox metabolism, in which NADPH is channelled into glutathione metabolism to reduce levels of reactive oxygen species and increase tolerance to oxidative stress.

    • Viridiana Olin-Sandoval
    • Jason Shu Lim Yu
    • Markus Ralser
    Research
    Nature
    Volume: 572, P: 249-253

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29