Malhi et al. conduct a high-throughput screen to identify inhibitors of respiratory syncytial virus (RSV). They find that statins inhibit post-entry events in the replicative cycle of RSV through a combination of cholesterol and isoprenoid-mediated effects, the latter involving a loss of Rho GTPase activity via disruption of protein prenylation.
- Manpreet Malhi
- Michael J. Norris
- Jason T. Maynes
