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Showing 1–3 of 3 results
Advanced filters: Author: Jason T. Swinderman Clear advanced filters

  • Yang et al. show that transcription–replication collisions lead to large tandem duplications, which are frequent in female-enriched, upper gastrointestinal tract and prostate cancers and are associated with poor survival and mutations in specific genes, such as CDK12.

    • Yang Yang
    • Michelle L. Badura
    • Lixing Yang
    Research
    Nature Cancer
    Volume: 5, P: 1885-1901

  • Schwannomas are regularly treated with radiotherapy, but the molecular effects on these tumours and their microenvironment remain unclear. Here, the authors show that radiotherapy can induce epigenetic reprogramming and immune infiltration in schwannomas, and develop the snARC-seq approach to analyse the epigenomic evolution at the single-cell level.

    • S. John Liu
    • Tim Casey-Clyde
    • David R. Raleigh
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics data to show that KIF4A and WDR62 drive aggressive prostate cancer phenotypes.

    • Rajdeep Das
    • Martin Sjöström
    • Luke A. Gilbert
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12