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The effect of a cumulative emission of carbon on peak global mean surface temperature is better constrained than the effect of stabilizing the atmospheric composition. The approach is also insensitive to the timing or peak rate of emissions. Using carbon cycle models, it is shown that a trillion tonnes of carbon emissions (about half of which has already been emitted since industrialization began) will produce a most likely peak warming of 2 degrees Celsius.

Agriculture sustains a large and growing human population, but generates widespread impacts. This study assesses the health effects of air pollution caused by maize production. Reduced air quality leads to 4,300 premature deaths annually in the United States, akin to US$39 billion in damages, and climate change damages of US$4.9 billion.

This study projects the private costs and monetized climate and health damages of electrifying long-haul heavy-duty diesel trucks. Battery electric trucks yield net positive societal benefits by 2035, contingent on policies that accelerate adoption.

Use of an enhanced suite of marine ecosystem models and Earth system model outputs from Phase 6 of the Coupled Model Intercomparison Project (CMIP6) reveals greater decline in mean global ocean animal biomass than previously projected under both strong-mitigation and high-emissions scenarios.

Copper-based catalysts are promising for electroreduction of carbon monoxide to multi-carbon products, yet further improvements in selectivity, productivity and stability are still needed. Here the authors show that doping copper with silver and ruthenium boosts its performance towards synthesis of n-propanol—a useful fuel.

Emissions targets must be placed in the context of a cumulative carbon budget if we are to avoid dangerous climate change.

Mitigation of greenhouse gas emissions often reduces co-emitted air pollutants, with advantages for human health. Avoided mortality from air pollution, a co-benefit of CO₂ abatement, is estimated under global climate change mitigation scenarios to be in the range of US$50–US$380 per tonne of CO₂. This exceeds the projected mitigation costs for 2030 and 2050, and is within the lower range of costs expected in 2100.

In the United States, green infrastructure may be less energy and carbon-intensive than gray infrastructure and generate substantial carbon credit revenue, accelerating water quality trading, according to an analysis of data on impaired waters, technologies, and life cycle accounting.

The discovery of the world's largest snake has important implications for our understanding of the evolution of global climate. The snake, a relative of the boa constrictor, was 13 metres long and would have weighed more than a tonne. It lived in tropical South America around 60 million years ago. A snake this size would have required mean annual temperatures between 30–34 °C, higher than the tropics today.

Decoupling emission reduction target determination, air pollution modelling, and health benefit estimation complicates control strategy design. Here an integrated approach identifies strategies to reduce health damages of air pollution, showing that benefits can be achieved cost-effectively by electrifying sources with high primary PM_2.5 emission intensities.

Some countries are disproportionately responsible for climate change damages and should compensate those remaining within fair shares of the 1.5 °C carbon budget. This study presents a procedure to quantify the level of compensation owed in a ‘net zero’ scenario where all countries decarbonize by 2050.

Political interests, not scientists or inventors, will be the biggest influence on technologies to counter climate change, says Jason Blackstock.

A cubic metre of tellurium held at cryogenic temperatures over many years has enabled a search for matter created in a rare nuclear process. The feat bodes well for stabilizing other complex systems at low temperatures.

Jason Clay identifies eight steps that, taken together, could enable farming to feed 10 billion people and keep Earth habitable.

Results show meaningful variations in electric vehicle costs and emissions benefits across the United States, differing by vehicle category and charging systems: Direct Current Fast Charging, Battery Swapping, and Dynamic Wireless Power Transfer.

Including passive CO₂ uptake as an anthropogenic removal in greenhouse gas accounting systems could undermine the Paris Agreement; measures to address this include acknowledging the need for Geological Net Zero and disaggregated accounting for carbon sinks.

In this Review, Rajagopalan and colleagues summarize the sources of greenhouse gas emissions related to the provision of cardiovascular health care and suggest strategies to reduce carbon emissions and costs, including the use of renewable energy, waste reduction and disease prevention.

Oncolytic viruses create an inflamed tumour microenvironment allowing T cells to respond to immune checkpoint blockade therapy more efficiently. Authors here show that in a hepatocellular carcinoma model, a dominant anti-viral rather than anti-tumour T cell response is elicited by an oncolytic vesicular stomatitis virus, unless the virus is designed to express tumour antigens, which restores therapeutic benefit.

Climate change is one of humankind’s biggest challenges, leading to more frequent and intense climate extremes, including heatwaves, wildfires, hurricanes, ocean acidification, and increased extinction rates. Nanotechnology already plays an important role in decarbonizing critical processes. Still, despite the technical advances seen in the last decades, the International Energy Agency has identified many sectors that are not on track to achieve the global climate mitigation goals by 2030. Here, a multi-stakeholder group of nanoscientists from the public, private, and philanthropic sectors discuss four high-potential application spaces where nanotechnologies could accelerate progress: batteries and energy storage; catalysis; coatings, lubricants, membranes, and other interface technology; and capture of greenhouse gases. This Comment highlights opportunities and current gaps for those working to minimize the climate crisis and provides a framework for the nanotechnology community to answer the call to action on this global issue.

Combining saline water electrolysis with mineral weathering powered by non-fossil electricity could produce low-cost, negative-CO₂-emissions energy.

Electrocatalytic NO_x reduction (NO_xR) to ammonia has recently become an increasingly popular alternative to the more challenging N₂ reduction. This Perspective critically assesses the possible ways NO_xR could contribute to the ammonia economy and clarifies the necessary steps for a rigorous experimental protocol.

Oncolytic viruses, such as vesicular stomatitis virus (VSV), are a promising class of cancer therapeutics. Here the authors report that a mutation in the CSDE1 gene renders cancer cells resistant to VSV replication and oncolysis, but a mutation-derived escape-associated neoantigen could be exploited for immunotherapy against treatment-resistant tumors.

DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to generate heteroclitic neoepitopes, enhancing sensitivity to immunotherapy.

Oncolytic viruses promote an inflammatory response and elicit anti-tumor immunity. Here the authors show, unexpectedly, that the oncolytic virus, VSVIFNβ, induces type I interferon responses that, when combined with chimeric antigen receptor (CAR) T therapy, lead to the attrition of both CAR T and conventional T cells, thus dampening their anti-tumor activity.

The Trump administration's domestic plans would have curtailed the nation's climate action even if it had stayed in the Paris Agreement. Yet, the decision to leave the agreement undermines US international energy and climate leadership and the prospects of ramping up global climate policy ambition.

The wastewater treatment industry contributes approximately 1.6% of greenhouse gas emissions. This Review analyses alternative wastewater treatment pathways for simultaneous CO₂ capture and utilization and shows the multiple benefits of microbial electrochemical and phototrophic processes.