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Showing 1–9 of 9 results
Advanced filters: Author: Jaspreet Sandhu Clear advanced filters

  • Radical prostatectomy can damage urinary function, causing incontinence. This incontinence typically resolves by the end of the first postoperative year, but it can be expedited by pelvic floor muscle exercises (PFME). A recent randomized controlled trial has demonstrated that PFME can be effective even when started years after surgery.

    • Bilal Chughtai
    • Jaspreet S. Sandhu
    News & Views
    Nature Reviews Urology
    Volume: 8, P: 237-238

  • The small size (≤15-nt) of micorexons poses difficulties for genome annotation and identification using standard RNA sequence mapping approaches. Here, the authors develop computational pipelines to discover and predict microexons in plants and reveal diverse evolutionary trajectories via genomewide microexon modeling.

    • Huihui Yu
    • Mu Li
    • Chi Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Crop production depends to a very large extent on phosphorus fertilization, yet the sustainability of this practice is limited by the predicted exhaustion of phosphorus resources. A new molecular pathway regulating phosphorus accumulation in plants has been identified, with PHO1 found to play a pivotal role in mediating it.

    • Jaspreet Sandhu
    • Hatem Rouached
    News & Views
    Nature Plants
    Volume: 8, P: 986-987

  • Stress urinary incontinence affects most men who undergo radical prostatectomy. This dysfunction will spontaneously resolve within 12 months for most patients—exercising the pelvic floor has been shown to hasten recovery. There are a number of surgical options for men in whom the condition persists.

    • Jaspreet S. Sandhu
    Reviews
    Nature Reviews Urology
    Volume: 7, P: 222-228

  • The activation of lipid X receptors (LXRs) in mouse liver not only promotes cholesterol efflux but also inhibits cholesterol synthesis simultaneously; this is mediated by the lipid-responsive long non-coding RNA LeXis, which is induced by a Western diet and orchestrates crosstalk between LXRs and the cholesterol biosynthetic pathway.

    • Tamer Sallam
    • Marius C. Jones
    • Peter Tontonoz
    Research
    Nature
    Volume: 534, P: 124-128

  • Incontinence is a common complication of radical prostatectomy and can have a considerable effect on quality of life for men who have survived prostate cancer. In the past, management of postoperative incontinence has focused on rehabilitation and postsurgical management, but prehabilitation, in the form of pelvic floor muscle exercises and training, has the potential to improve postprostatectomy continence outcomes, provide patients with agency for their own health and improve quality of life in men who have been treated for prostate cancer.

    • Sean F. Mungovan
    • Sigrid V. Carlsson
    • Manish I. Patel
    Reviews
    Nature Reviews Urology
    Volume: 18, P: 259-281