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Showing 1–4 of 4 results
Advanced filters: Author: Jaswir Basran Clear advanced filters

  • The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to directly observe a protonated ferryl intermediate in a heme peroxidase.

    • Hanna Kwon
    • Jaswir Basran
    • Emma L. Raven
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-6

  • Despite being highly toxic, carbon monoxide (CO) is also essential as an intracellular signalling molecule, but CO-dependent signalling is poorly understood. Here, authors employ spectroscopic and electrophysiology methods and find that CO activates KATP channels via SUR2A, a heme-regulated receptor.

    • Sofia M. Kapetanaki
    • Mark J. Burton
    • Emma Raven
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10