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Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

Developing anti-gout medications that simultaneously reduce uric acid and exert anti-inflammatory effects is of interest for managing gout progression. Here, the authors employ a dual-target pharmacophore model to design derivatives of β-carboline-1-propionic acid and identify a drug candidate demonstrating potent uric acid-lowering activity in male hyperuricemia mouse models and mitigating NLRP3-mediated inflammation.

Zhijiao Zhang
Xiaoyu Shi
Peng Zhan
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Outcomes of 207 totally extraperitoneal hernia repairs using self-fixation mesh

Felipe Girón
Juan David Hernandez
Ricardo Nassar
ResearchOpen Access15 Jun 2021
Scientific Reports

Volume: 11, P: 1-7
Evidence of thrust faulting and widespread contraction of Ceres

Contractional features such as scarps, ridges and fractures from thrust faults are typical of large silicate bodies such as Mercury and Mars. Evidence for similar features on Ceres suggests the possibility of large-scale contraction on this icy body.

Javier Ruiz
Alberto Jiménez-Díaz
Michael Küppers
Research01 Jul 2019
Nature Astronomy

Volume: 3, P: 916-921
Na⁺ controls hypoxic signalling by the mitochondrial respiratory chain

Na⁺ controls the function of the mitochondrial oxidative phosphorylation system and hypoxic redox signalling through an unexpected interaction with phospholipids.

Pablo Hernansanz-Agustín
Carmen Choya-Foces
Antonio Martínez-Ruiz
Research29 Jul 2020
Nature

Volume: 586, P: 287-291
Annotated Spanish general election debate transcriptions 1993-2023

Fermín L. Cruz
Fernando Enríquez
José A. Troyano
ResearchOpen Access29 Sept 2025
Scientific Data

Volume: 12, P: 1-9
Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility

A GWAS in a large case-control cohort of European ancestry identifies two genomic regions, the MHC class II gene HLA-DRB1 and an upstream locus of VRK1, that are associated with the most severe phenotype of spermatogenic failure.

Miriam Cerván-Martín
Frank Tüttelmann
F. David Carmona
ResearchOpen Access10 Nov 2022
Communications Biology

Volume: 5, P: 1-13
Prospective multicenter study to identify optimal target population for motorized spiral enteroscopy

Antonio Giordano
Luis Compañy
Begoña González-Suárez
ResearchOpen Access22 Jul 2024
Scientific Reports

Volume: 14, P: 1-9
Un-biased housekeeping gene panel selection for high-validity gene expression analysis

Ana I. Casas
Ahmed A. Hassan
Harald H. H. W. Schmidt
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-12
Sleep-disordered breathing, circulating exosomes, and insulin sensitivity in adipocytes

Abdelnaby Khalyfa
David Gozal
F Javier Barca
Research11 Jun 2018
International Journal of Obesity

Volume: 42, P: 1127-1139
Habitat type modulates sharp body mass oscillations in cyclic common vole populations

Pedro P. Olea
Noelia de Diego
Javier Viñuela
ResearchOpen Access26 May 2024
Scientific Reports

Volume: 14, P: 1-14
Determinants of patient satisfaction in clozapine users: results from the Clozapine International Consortium (CLOZIN)

Marte Z. van der Horst
Nini de Boer
Jurjen J. Luykx
ResearchOpen Access23 Feb 2025
Schizophrenia

Volume: 11, P: 1-8
Ex vivo assessment and in vivo validation of non-invasive stent monitoring techniques based on microwave spectrometry

Carolina Gálvez-Montón
Gianluca Arauz-Garofalo
Javier Tejada
ResearchOpen Access04 Oct 2018
Scientific Reports

Volume: 8, P: 1-8

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Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

Outcomes of 207 totally extraperitoneal hernia repairs using self-fixation mesh

Evidence of thrust faulting and widespread contraction of Ceres

Na⁺ controls hypoxic signalling by the mitochondrial respiratory chain

Annotated Spanish general election debate transcriptions 1993-2023

Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility

Prospective multicenter study to identify optimal target population for motorized spiral enteroscopy

Un-biased housekeeping gene panel selection for high-validity gene expression analysis

Sleep-disordered breathing, circulating exosomes, and insulin sensitivity in adipocytes

Habitat type modulates sharp body mass oscillations in cyclic common vole populations

Determinants of patient satisfaction in clozapine users: results from the Clozapine International Consortium (CLOZIN)

Ex vivo assessment and in vivo validation of non-invasive stent monitoring techniques based on microwave spectrometry

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