Nature Search

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis

SFRP1, an ADAM10 inhibitor, is elevated in the brains of patients with Alzheimer’s disease (AD). Antibody-mediated neutralization of its activity stalls brain alterations and cognitive loss in AD-like mice, supporting SFRP1 as a potential target for disease therapy.

Pilar Esteve
Javier Rueda-Carrasco
Paola Bovolenta
Research15 Jul 2019
Nature Neuroscience

Volume: 22, P: 1258-1268
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least in tauopathies caused by tau isoform imbalance.

Naoto Watamura
Martha S. Foiani
Takaomi C. Saido
ResearchOpen Access24 Dec 2024
Nature Neuroscience

Volume: 28, P: 293-307
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

Microglia mediate aberrant synapse engulfment in Alzheimer’s disease (AD), but the underlying mechanisms are poorly understood. Here the authors show a perivascular cells-to-microglia crosstalk that induces microglia phagocytic state resulting in synapse engulfment in two mouse models of AD.

Sebastiaan De Schepper
Judy Z. Ge
Soyon Hong
ResearchOpen Access06 Feb 2023
Nature Neuroscience

Volume: 26, P: 406-415
Sfrp1 deficiency makes retinal photoreceptors prone to degeneration

Elsa Cisneros
Fabiana di Marco
Paola Bovolenta
ResearchOpen Access20 Mar 2020
Scientific Reports

Volume: 10, P: 1-16

Quick links

Search

Filter By:

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

Sfrp1 deficiency makes retinal photoreceptors prone to degeneration

Search

Quick links