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Showing 1–3 of 3 results
Advanced filters: Author: Javier Yu Peng Koh Clear advanced filters

  • Heterogeneous geminal-atom catalysts, which pair single-atom sites in specific coordination and spatial proximity, offer a new avenue for the sustainable manufacture of fine chemicals.

    • Xiao Hai
    • Yang Zheng
    • Jiong Lu
    Research
    Nature
    Volume: 622, P: 754-760

  • There exist challenges in quantifying the length of individual telomeres at single nucleotide resolution. Here the authors report a method to capture telomeres and accurately analyse their length in human cell lines and patient peripheral blood leukocyte samples using single-molecule real-time sequencing.

    • Cheng-Yong Tham
    • LaiFong Poon
    • Shang Li
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • ATP-binding cassette transporter ABCB1 is known to be involved in drug resistance in cancer treatment, however, current ABCB1 inhibitors have not been successful in clinical trials due to their potential cytotoxicity. Here, the authors hypothesize that potential ABCB1 substrates in bats could act as competitive inhibitors against ABCB1 in humans, and identify the tryptophan structure as a promising lead structure for the development of non-toxic ABCB1 inhibitors.

    • Javier Yu Peng Koh
    • Yoko Itahana
    • Koji Itahana
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-17