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Showing 1–3 of 3 results
Advanced filters: Author: Jay Bradner Clear advanced filters

  • A selection of individuals from the biotech ecosystem give their views on the challenges facing the sector over the coming years.

    • Anu Acharya
    • Kate Bingham
    • Daphne Zohar
    Special Features
    Nature Biotechnology
    Volume: 34, P: 276-283

  • Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets the deacetylase (HDAC1) and demethylase (LSD1) activities of the CoREST complex.

    • Jay H. Kalin
    • Muzhou Wu
    • Philip A. Cole
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13