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Showing 1–5 of 5 results
Advanced filters: Author: Jay F. Sarthy Clear advanced filters

  • Automated and single-cell CUT&Tag is used to characterize the effects of KMT2A fusion proteins on chromatin in human primary leukemia samples, identifying oncogenic networks and fusion-specific therapeutic vulnerabilities.

    • Derek H. Janssens
    • Michael P. Meers
    • Steven Henikoff
    ResearchOpen Access
    Nature Genetics
    Volume: 53, P: 1586-1596

  • The effects of chromosomal translocations involving the mixed-lineage leukemia (MLL) locus on gene expression regulation remain to be explored. Here, the authors find that MLL oncoproteins support lineage-switching events through dynamic chromatin binding.

    • Derek H. Janssens
    • Melodie Duran
    • Steven Henikoff
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.

    • Guo-Liang Chew
    • Marie Bleakley
    • Jay Sarthy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.

    • Maged Zeineldin
    • Sara Federico
    • Michael A. Dyer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20