Nature Search

Ice-age hurricanes and tropical storms

Jay S. Hobgood
Randall S. Cerveny
Research19 May 1988
Nature

Volume: 333, P: 243-245
Severe and widespread coral reef damage during the 2014-2017 Global Coral Bleaching Event

From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

C. Mark Eakin
Scott F. Heron
Derek P. Manzello
ResearchOpen Access10 Feb 2026
Nature Communications

Volume: 17, P: 1-14
Development of Asian monsoon revealed by marked ecological shift during the latest Miocene in northern Pakistan

Jay Quade
Thure E. Cerling
John R. Bowman
Research09 Nov 1989
Nature

Volume: 342, P: 163-166
Surface particle transport mechanism independent of myosin II in Dictyostelium

Patrick Y. Jay
Elliot L. Elson
Research02 Apr 1992
Nature

Volume: 356, P: 438-440
Expansion of C4 ecosystems as an indicator of global ecological change in the late Miocene

Thure E. Cerling
Yang Wang
Jay Quade
Research28 Jan 1993
Nature

Volume: 361, P: 344-345
Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C

Paul F. Worley
Jay M. Baraban
Solomon H. Snyder
Research08 Jan 1987
Nature

Volume: 325, P: 159-161
Activation of Statl by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

Wu-Chou S. Su
Motoo Kitagawa
Xin-Yuan Fu
Research20 Mar 1997
Nature

Volume: 386, P: 288-292
Author Correction: Binary vector copy number engineering improves Agrobacterium-mediated transformation

Matthew J. Szarzanowicz
Lucas M. Waldburger
Patrick M. Shih
Amendments and CorrectionsOpen Access24 Nov 2025
Nature Biotechnology

Volume: 43, P: 2068
Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder

Alcohol use disorder drives transcriptional and regulatory changes in the caudate nucleus. Here, authors show, using a single-cell multiomic analysis, cell type-specific disruptions of gene expression, chromatin accessibility, and cell communication.

Nicholas C. Green
Hongyu Gao
Yunlong Liu
ResearchOpen Access13 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Binary vector copy number engineering improves Agrobacterium-mediated transformation

Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants.

Matthew J. Szarzanowicz
Lucas M. Waldburger
Patrick M. Shih
ResearchOpen Access04 Nov 2024
Nature Biotechnology

Volume: 43, P: 1708-1716
Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production

Malonyl-CoA (M-CoA) is essential for polyketide biosynthesis, but its limited availability constrains production. Here the authors engineer and evolve an orthogonal M-CoA pathway in Escherichia coli to improve M-CoA metabolism, increasing M-CoA levels and polyketide yields.

Sarah H. Klass
Mia Wesselkamper
Jay D. Keasling
ResearchOpen Access11 Jun 2025
Nature Chemical Biology

Volume: 21, P: 1214-1225
Fast growth and high-titer bioproduction from renewable formate via metal-dependent formate dehydrogenase in Escherichia coli

Low formate dehydrogenase (FDH) activity limits formate assimilation via the synthetic reductive glycine pathway. In this study, the authors introduce a faster FDH in synthetic formatotrophic E. coli, which boosts growth rates and bioproduction titers from formate as sole carbon source.

Aidan E. Cowan
Mason Hillers
Nico J. Claassens
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Engineered CD47 protects T cells for enhanced antitumour immunity

Combination of TCR or CAR T cells expressing the engineered CD47 variant 47_E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance by macrophages, while maintaining macrophage recruitment into the tumour microenvironment.

Sean A. Yamada-Hunter
Johanna Theruvath
Crystal L. Mackall
ResearchOpen Access15 May 2024
Nature

Volume: 630, P: 457-465
FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation

Bladder cancer can often exhibit genomic and morphological heterogeneity. Here, the authors use genomics analysis to show lineage plasticity of bladder cancers with squamous differentiation, and identify key transcription factors related to this morphological and immune heterogeneity.

Joshua I. Warrick
Wenhuo Hu
Hikmat A. Al-Ahmadie
ResearchOpen Access02 Nov 2022
Nature Communications

Volume: 13, P: 1-17
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Autosomal dominant polycystic kidney disease (ADPKD) is a complicated disease that involves numerous cell types. Here the authors used a multiomics approach consisting of single nucleus transcriptomes and epigenomes to redefine cell states in ADPKD and to dissect the cellular interactions and molecular mechanisms of ADPKD.

Yoshiharu Muto
Eryn E. Dixon
Benjamin D. Humphreys
ResearchOpen Access30 Oct 2022
Nature Communications

Volume: 13, P: 1-19
Inhibition versus induction of apoptosis by proteasome inhibitors depends on concentration

Kuo-I Lin
Jay M Baraban
Rajiv R Ratan
Research10 Jul 1998
Cell Death & Differentiation

Volume: 5, P: 577-583
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition

Propionate addition is a common strategy for production of valuable polyketides by supplying the substrate methylmalonyl-CoA in the industrial microbe Corynebacterium glutamicum; however, propionate inhibits C. glutamicum growth, thus hampering polyketide production. In this study, Zhan et al. identify the reasons for propionate-elicited growth inhibition and metabolically engineer C. glutamicum to circumvent this roadblock and increase polyketide production.

Chunjun Zhan
Namil Lee
Jay D. Keasling
Research13 Jul 2023
Nature Metabolism

Volume: 5, P: 1127-1140
Device simulations with A U-Net model predicting physical quantities in two-dimensional landscapes

Wen-Jay Lee
Wu-Tsung Hsieh
Nan-Yow Chen
ResearchOpen Access13 Jan 2023
Scientific Reports

Volume: 13, P: 1-9
Racial disparities in ophthalmology clinical trials: barriers to participation and potential solutions

Kerollos Kamel
Amy J. Yu
Jay Chhablani
Reviews29 Nov 2025
Eye

Volume: 40, P: 302-309
Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation

Joshua I. Warrick
Wenhuo Hu
Hikmat A. Al-Ahmadie
Amendments and CorrectionsOpen Access23 Dec 2022
Nature Communications

Volume: 13, P: 1
Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

Late-onset Alzheimer's disease (LOAD) is a complex multi-factorial disorder. Here, the authors perform a data-driven analysis of LOAD progression, including multimodal brain imaging, plasma and CSF biomarkers, and find vascular dysfunction is among the earliest and strongest altered events.

Y. Iturria-Medina
R. C. Sotero
Ansgar J. Furst
ResearchOpen Access21 Jun 2016
Nature Communications

Volume: 7, P: 1-14
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

This study finds that sST2 is a disease-causing factor for Alzheimer’s disease. Higher sST2 levels impair microglial Aβ clearance in APOE4⁺ female individuals. A genetic variant, rs1921622, is associated with a reduction in sST2 level and protects against AD in APOE4⁺ female individuals.

Yuanbing Jiang
Xiaopu Zhou
Nancy Y. Ip
ResearchOpen Access15 Jul 2022
Nature Aging

Volume: 2, P: 616-634
Health-care spending and utilization for children discharged from a neonatal intensive care unit

Dennis Z. Kuo
Jay G. Berry
Christopher J. Stille
Research15 Feb 2018
Journal of Perinatology

Volume: 38, P: 734-741
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

Alexandra L Young
Razvan V Marinescu
Ansgar J Furst
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-16
The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The BIN1 SNP rs744373 is associated with higher CSF tau and phosphorylated tau levels. Here the authors show, using PET imaging, that this SNP is associated with tau accumulation in the brain as well as impaired memory in older individuals without dementia.

Nicolai Franzmeier
Anna Rubinski
Ansgar J. Furst
ResearchOpen Access16 Apr 2019
Nature Communications

Volume: 10, P: 1-12
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical diagnosis to show that tissue volume changes appear earlier in the basal forebrain than in the entorhinal cortex.

Taylor W. Schmitz
R. Nathan Spreng
Ansgar J. Furst
ResearchOpen Access04 Nov 2016
Nature Communications

Volume: 7, P: 1-13
Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

Brain-iron elevation is implicated in Alzheimer’s disease (AD), but the impact of the metal on disease outcomes has not been analysed in a longitudinal study. Here, the authors examine the association between the levels of ferritin, an iron storage protein, in the cerebrospinal fluid (CSF) of AD patients and show that CSF ferritin levels predict AD outcomes.

Scott Ayton
Noel G. Faux
Ansgar J. Furst
ResearchOpen Access19 May 2015
Nature Communications

Volume: 6, P: 1-9
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access25 Jul 2019
Nature Communications

Volume: 10, P: 1-16
PRISMA AI reporting guidelines for systematic reviews and meta-analyses on AI in healthcare

Giovanni E. Cacciamani
Timothy N. Chu
Andrew J. Hung
Correspondence16 Jan 2023
Nature Medicine

Volume: 29, P: 14-15
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
Amendments and CorrectionsOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1
Effects of decadal climate variability on spatiotemporal distribution of Indo-Pacific yellowfin tuna population

Yan-Lun Wu
Kuo-Wei Lan
Jui-Wen Chan
ResearchOpen Access12 Aug 2022
Scientific Reports

Volume: 12, P: 1-13
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes

Frank A. Petrigliano
Nancy Q. Liu
Denis Evseenko
ResearchOpen Access23 Nov 2021
npj Regenerative Medicine

Volume: 6, P: 1-14
Physical biology of the cancer cell glycocalyx

It may look like little more than slime, but the glycocalyx coating our cells plays a key role in cell signalling. And changes to its physical structure have been linked to cancer, triggering emergent behaviours that form the focus of this Review.

Joe Chin-Hun Kuo
Jay G. Gandhi
Matthew J. Paszek
Reviews04 Jul 2018
Nature Physics

Volume: 14, P: 658-669
Genetic nurture effects for alcohol use disorder

Nathaniel S. Thomas
Jessica E. Salvatore
Denise Scott
Research17 Oct 2022
Molecular Psychiatry

Volume: 28, P: 759-766
Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function

Peng Fei
Juhyun Lee
Tzung K. Hsiai
ResearchOpen Access03 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders

Stacey Saenz de Viteri
Jian Zhang
Jacquelyn L. Meyers
ResearchOpen Access21 Jun 2023
Molecular Psychiatry

Volume: 28, P: 3391-3396
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

Dina Popova
Isabel Gameiro-Ros
Ronald P. Hart
Research07 Oct 2022
Molecular Psychiatry

Volume: 28, P: 746-758
The trend of disruption in the functional brain network topology of Alzheimer’s disease

Alireza Fathian
Yousef Jamali
Ansgar J. Furst
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-17
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

Jorim J. Tielbeek
Emil Uffelmann
Danielle Posthuma
Research25 Oct 2022
Molecular Psychiatry

Volume: 27, P: 4453-4463
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

Suprateek Kundu
Joshua Lukemire
Ansgar J. Furst
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-18
Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3^p53−/− mice

Daniel J Powell Jr
John P Russell
Jay L Rothstein
Research22 Jun 2001
Oncogene

Volume: 20, P: 3235-3246
Impact of COVID-19 pandemic on global unrelated stem cell donations in 2020—Report from World Marrow Donor Association

Monique M. Jöris
Alexander H. Schmidt
Lydia Foeken
Correspondence09 Apr 2022
Bone Marrow Transplantation

Volume: 57, P: 1021-1024

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