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Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling

HIV-1 TAR RNA plays key roles in viral replication, transcription, and translation. Here, Bou-Nader et al., portray the structure, dynamics, and interactions of a complete TAR RNA, and uncovers a convergent viral strategy to evade innate immunity.

Charles Bou-Nader
Katie A. Link
Jinwei Zhang
ResearchOpen Access06 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture

The recently discovered aptamer Beetroot is a homodimeric RNA that binds and activates DFAME, a conditional, red-shifted fluorophore derived from GFP. Here the authors determine the Beetroot-DFAME co-crystal structure, which is distinctively different from that of similar RNA aptamer Corn.

Luiz F. M. Passalacqua
Mary R. Starich
Adrian R. Ferré-D’Amaré
ResearchOpen Access23 May 2023
Nature Communications

Volume: 14, P: 1-12
Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

Structural analysis of Mango-III in complex with fluorophores reveals a globular architecture and a planar conformation of fluorophores. Structure-guided mutation and functional reselection identified two mutants with improved fluorescence intensity.

Robert J. Trachman III
Alexis Autour
Adrian R. Ferré-D’Amaré
Research15 Apr 2019
Nature Chemical Biology

Volume: 15, P: 472-479
Partition of Myc into Immobile vs. Mobile Complexes within Nuclei

Tilman Rosales
Zuqin Nie
David Levens
ResearchOpen Access06 Jun 2013
Scientific Reports

Volume: 3, P: 1-8
Cerebrospinal Fluid Monoaminergic Metabolites Differ in Wild Anubis and Hybrid (Anubis hamadryas) Baboons: Possible Relationships to Life History and Behavior

Jay R Kaplan
Jane Phillips-Conroy
J John Mann
Research01 Jun 1999
Neuropsychopharmacology

Volume: 20, P: 517-524
Social Impulsivity Inversely Associated with CSF 5-HIAA and Fluoxetine Exposure in Vervet Monkeys

Lynn A Fairbanks
William P Melega
Michael T McGuire
Research01 Apr 2001
Neuropsychopharmacology

Volume: 24, P: 370-378

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Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling

Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

Partition of Myc into Immobile vs. Mobile Complexes within Nuclei

Cerebrospinal Fluid Monoaminergic Metabolites Differ in Wild Anubis and Hybrid (Anubis hamadryas) Baboons: Possible Relationships to Life History and Behavior

Social Impulsivity Inversely Associated with CSF 5-HIAA and Fluoxetine Exposure in Vervet Monkeys

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