Avidor-Reiss and colleagues show that the nucleotide status of tubulin regulates recruitment of pericentriolar material. Binding of GTP-bound tubulin to the Sas-4 centrosomal protein prevents the Sas-4-dependent formation of centrosomal protein complexes, whereas the Sas-4-stimulated hydrolysis of tubulin–GTP into tubulin–GDP has the opposite effect.
- Jayachandran Gopalakrishnan
- Yiu-Cheung Frederick Chim
- Tomer Avidor-Reiss
