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Showing 1–8 of 8 results
Advanced filters: Author: Jayati Basu Clear advanced filters

  • Basu et al. find that the transcription factor ThPOK is not restricted to T cells, as it also is expressed in myeloid cell progenitors and contributes to the lineage choice of monocyte-dendritic cells as opposed to neutrophils.

    • Jayati Basu
    • Andre Olsson
    • Dietmar J. Kappes
    Research
    Nature Immunology
    Volume: 24, P: 1295-1307

  • Basu Jayati et al. examine how T-cell receptor (TCR) engagement with MHC ligands can contribute toward adoption of CD4 and CD8 cell fates during development. By using an in vivo mutagenesis approach in mice, their results suggest potential mechanisms linking TCR signaling to ThPOK expression and differential immune lineage choice.

    • Jayati Basu
    • Jikun Zha
    • Dietmar J. Kappes
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-18

  • The transcription factors TCF-1 and LEF-1 have diverse roles in differentiation into the CD4+ lineage through means both dependent on and independent of the transcription factor Th-POK.

    • Jayati Mookerjee-Basu
    • Dietmar J Kappes
    News & Views
    Nature Immunology
    Volume: 15, P: 593-594

  • Altered signaling via the T cell antigen receptor (TCR) promotes an adipose-tissue-like phenotype in invariant natural killer cells (iNKT cells) during thymic development and causes selective enrichment for iNKT cells in adipose tissues.

    • Jayati Mookerjee-Basu
    • Dietmar J Kappes
    News & Views
    Nature Immunology
    Volume: 18, P: 10-12

  • The BRCA1-PALB2-BRCA2-RAD51 (BRCA1-P) complex is well known to play a fundamental role in DNA repair, but how the complex recruitment is regulated is still a matter of interest. Here the authors reveal mechanistic insights into RNF168 activity being responsible for PALB2 recruitment, through BARD1-BRCA1 during homologous recombination repair.

    • John J. Krais
    • Yifan Wang
    • Neil Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The transcription factor ThPOK is critical for homeostasis and differentiation of mature helper T cells. Here, Kappes and colleagues describe a ThPOK-mediated positive autoregulatory loop that is crucial for tissue-specific Treg cell differentiation, maintenance of intestinal Treg cell integrity and conversion of these cells into CD4+ intraepithelial lymphocytes.

    • Jayati Basu
    • Bernardo S. Reis
    • Dietmar J. Kappes
    Research
    Nature Immunology
    Volume: 22, P: 969-982