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Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder

The cellular signatures of the opioid exposed human midbrain remain unexplored. Here, authors show by single nuclei transcriptomics activation of the glial immune response and dysregulation of synaptic signaling in opioid exposed individuals

Julong Wei
Tova Y. Lambert
Schahram Akbarian
ResearchOpen Access12 Sept 2023
Nature Communications

Volume: 14, P: 1-13

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Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder

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