Nature Search

Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control

Quality control, including pluripotency testing of human iPSCs lacks standardization. Here, authors identify and validate gene markers to develop the machine learning-based hiPSCore to streamline pluripotency testing and elevate iPSC quality.

Jochen Dobner
Sebastian Diecke
Andrea Rossi
ResearchOpen Access02 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

Volume: 646, P: 1146-1155
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
Research18 Apr 2024
Nature Genetics

Volume: 56, P: 792-808
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR

PTSD has been associated with DNA methylation of specific loci in the genome, but studies have been limited by small sample sizes. Here, the authors perform a meta-analysis of DNA methylation data from 10 different cohorts and identify CpGs in AHRR that are associated with PTSD.

Alicia K. Smith
Andrew Ratanatharathorn
Caroline M. Nievergelt
ResearchOpen Access24 Nov 2020
Nature Communications

Volume: 11, P: 1-9
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
ResearchOpen Access08 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Large-scale Mendelian randomization and colocalization analyses using gene expression and soluble protein data for 1,263 actionable druggable genes, which encode protein targets for approved drugs or drugs in clinical development, identify IFNAR2 and ACE2 as the most promising therapeutic targets for early management of COVID-19.

Liam Gaziano
Claudia Giambartolomei
Juan P. Casas
Research09 Apr 2021
Nature Medicine

Volume: 27, P: 668-676
Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation

In this study, the authors present magnetoelectric nanodiscs that enable minimally invasive, remote magnetic neuromodulation with subsecond precision to drive reward and motor behaviours in genetically intact mice.

Ye Ji Kim
Noah Kent
Polina Anikeeva
ResearchOpen Access11 Oct 2024
Nature Nanotechnology

Volume: 20, P: 121-131
Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans

Kyle J. Bourassa
Melanie E. Garrett
Nathan A. Kimbrel
ResearchOpen Access06 Jan 2024
Translational Psychiatry

Volume: 14, P: 1-8
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as well as links to metabolic and cardiovascular diseases.

Raha Pazoki
Marijana Vujkovic
Rachel B. Ramoni
ResearchOpen Access10 May 2021
Nature Communications

Volume: 12, P: 1-12
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Genome-wide association meta-analyses among 1.4 million individuals identify 318 new risk loci for type 2 diabetes and provide insight into the contribution of these risk variants to diabetes-related vascular outcomes.

Marijana Vujkovic
Jacob M. Keaton
Danish Saleheen
Research15 Jun 2020
Nature Genetics

Volume: 52, P: 680-691
High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

Sayera Dhaubhadel
Kumkum Ganguly
Benjamin H. McMahon
ResearchOpen Access20 Jan 2024
Scientific Reports

Volume: 14, P: 1-19
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci

Nathan A. Kimbrel
Allison E. Ashley-Koch
Jean C. Beckham
Research28 Mar 2022
Molecular Psychiatry

Volume: 27, P: 2264-2272
Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior

Using the software GRIN, GWAS results are refined by reducing false positive genes using biological network topology, allowing users to lower GWAS significance thresholds to identify additional genes associated with complex traits

Kyle A. Sullivan
Matthew Lane
David Kainer
ResearchOpen Access21 Oct 2024
Communications Biology

Volume: 7, P: 1-16
Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder

Tim B. Bigdeli
Peter B. Barr
Philip D. Harvey
Research15 Mar 2024
Molecular Psychiatry

Volume: 29, P: 2399-2407
Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls

Rajendra A. Morey
Sarah L. Davis
Allison E. Ashley-Koch
ResearchOpen Access30 Nov 2017
Translational Psychiatry

Volume: 7, P: 1-10
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

Pavithra Nagarajan
Thomas W. Winkler
Heming Wang
Research04 Apr 2025
Molecular Psychiatry

Volume: 30, P: 3660-3672
FGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an intracrine pathway

Sylvina Bouleau
Hélène Grimal
Flore Renaud
Research01 Aug 2005
Oncogene

Volume: 24, P: 7839-7849
Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder

Rajendra A. Morey
Courtney C. Haswell
Kevin S. LaBar
Research28 Mar 2020
Neuropsychopharmacology

Volume: 45, P: 1380-1389
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume

Yuanchao Zheng
Melanie E. Garrett
Rajendra A. Morey
ResearchOpen Access16 Dec 2021
Translational Psychiatry

Volume: 11, P: 1-10
Threat-induced anxiety during goal pursuit disrupts amygdala–prefrontal cortex connectivity in posttraumatic stress disorder

Delin Sun
Andrea L. Gold
Rajendra A. Morey
ResearchOpen Access10 Feb 2020
Translational Psychiatry

Volume: 10, P: 1-11
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy

Xuan Wang
Molei Liu
Katherine P. Liao
ResearchOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Sarah M. C. Colbert
Eric T. Monson
Lea Zillich
ReviewsOpen Access25 Sept 2025
Molecular Psychiatry

Volume: 30, P: 6144-6154
Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder

R A Morey
J E Dunsmoor
K S LaBar
ResearchOpen Access15 Dec 2015
Translational Psychiatry

Volume: 5, P: e700
Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

Maithili Sashindranath
Andre Laval Samson
Robert Lindsay Medcalf
Research25 Apr 2011
Laboratory Investigation

Volume: 91, P: 1079-1091
Update on psychiatric genetics

Stephan Züchner
Sushma T Roberts
Jean C Beckham
Reviews01 Jun 2007
Genetics in Medicine

Volume: 9, P: 332-340
Altered Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes in Posttraumatic Stress Disorder

Vanessa M Brown
Kevin S LaBar
Rajendra A Morey
Research09 Aug 2013
Neuropsychopharmacology

Volume: 39, P: 351-359

Search

Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control

Polygenic and developmental profiles of autism differ by age at diagnosis

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation

Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci

Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior

Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder

Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

FGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an intracrine pathway

Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder

Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume

Threat-induced anxiety during goal pursuit disrupts amygdala–prefrontal cortex connectivity in posttraumatic stress disorder

Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy

Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder

Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

Update on psychiatric genetics

Altered Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes in Posttraumatic Stress Disorder

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