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Showing 1–2 of 2 results
Advanced filters: Author: Jean M. Etersque Clear advanced filters

  • The ability to control proteins in cells and animals is important for experimental research and may have therapeutic applications. Here, the authors developed a new set of heterobifunctional small molecules based on the antibiotic trimethoprim that can degrade proteins that are genetically tagged with E. coli dihydrofolate reductase (eDHFR).

    • Jean M. Etersque
    • Iris K. Lee
    • Mark A. Sellmyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • mRNA vaccines have been successfully developed, but a better understanding of in vivo distribution of the encoded antigen may aid further improvements. Here the authors use PET imaging and demonstrate transient expression of the vaccine antigen in the injection site and draining lymph nodes in mice and non-human primates.

    • Gabrielle S. Blizard
    • Garima Dwivedi
    • Mark A. Sellmyer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14