Nature Search

Is lipoprotein(a) a clinically meaningful risk marker for cardiovascular events in healthy women?

Jean-Charles Fruchart
Comments & Opinion13 Mar 2007
Nature Clinical Practice Cardiovascular Medicine

Volume: 4, P: 242-243
Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APC^Min/+ mice

Anne-Marie Lefebvre
Inhua Chen
Johan Auwerx
Research01 Sept 1998
Nature Medicine

Volume: 4, P: 1053-1057
PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

Giulia Chinetti
Sophie Lestavel
Bart Staels
Research01 Jan 2001
Nature Medicine

Volume: 7, P: 53-58
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

Bart Staels
Wolfgang Koenig
Alain Tedgui
Research25 Jun 1998
Nature

Volume: 393, P: 790-793
Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors

Peroxisome proliferator-activated receptors (PPARs) are important regulators of energy homeostasis and inflammation. They modulate cardiovascular disease, type 2 diabetes and the metabolic syndrome. This Review describes these mechanisms, and the drugs that modulate PPARs and are in current clinical use, as well as potential new drug-development strategies targeting PPARs.

Philippe Gervois
Jean-Charles Fruchart
Bart Staels
Reviews01 Feb 2007
Nature Clinical Practice Endocrinology & Metabolism

Volume: 3, P: 145-156
Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity

In this Consensus Statement, the International Atherosclerosis Society and International Chair on Cardiometabolic Risk Working Group on Visceral Obesity recommend that waist circumference be included routinely as a measurement in clinical practice. They summarize the evidence that waist circumference and BMI together can provide improved assessments of cardiometabolic risk compared with either measurement alone.

Robert Ross
Ian J. Neeland
Jean-Pierre Després
ReviewsOpen Access04 Feb 2020
Nature Reviews Endocrinology

Volume: 16, P: 177-189
Glucose regulates LXRα subcellular localization and function in rat pancreatic β-cells

Audrey Helleboid-Chapman
Stéphane Helleboid
Jean-Charles Fruchart
Research13 Jun 2006
Cell Research

Volume: 16, P: 661-670
Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content

Yusuke Sasaki
Masato Asahiyama
Tatsuhiko Kodama
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-10

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