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Showing 1–2 of 2 results
Advanced filters: Author: Jean-Guy Delcros Clear advanced filters

  • Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway are currently being explored. Here the authors report a pro-apoptotic function of Notch3 in endothelial cells; consequently, when Notch3 is silenced in stroma cells, tumour growth and angiogenesis are increased.

    • Shuheng Lin
    • Ana Negulescu
    • Patrick Mehlen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modulate laminin-laminin interactions.

    • Raphael Reuten
    • Trushar R. Patel
    • Manuel Koch
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-17