Nature Search

Accelerated drug development using a digital formulator and a self-driving tableting data factory

Drug development is slowed down by manual formulation and testing. Here, the authors present an integrated digital formulator and self-driving tableting system that rapidly designs and manufactures tablets, thereby reducing material consumption and development time.

Faisal Abbas
Mohammad Salehian
Daniel Markl
ResearchOpen Access01 Apr 2026
Nature Communications

P: 1-16
Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein

Jean-Jacques Diaz
Madeleine Due Dodon
Jean-Jacques Madjar
Research18 Jan 1996
Nature

Volume: 379, P: 273-277
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 loci associated with QT interval and highlight a role for calcium regulation in myocardial repolarization.

Dan E Arking
Sara L Pulit
Christopher Newton-Cheh
Research22 Jun 2014
Nature Genetics

Volume: 46, P: 826-836
Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Connie R Bezzina
Julien Barc
Richard Redon
Amendments and Corrections29 Oct 2013
Nature Genetics

Volume: 45, P: 1409
Genetic testing and quality control in diagnostic laboratories

Elisabeth Dequeker
Jean-Jacques Cassiman
Research01 Jul 2000
Nature Genetics

Volume: 25, P: 259-260
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Genome-wide association analyses identify new susceptibility loci for Brugada syndrome. Functional studies implicate microtubule-related trafficking effects on sodium channel expression as an underlying molecular mechanism.

Julien Barc
Rafik Tadros
Connie R. Bezzina
Research24 Feb 2022
Nature Genetics

Volume: 54, P: 232-239
A Middle Miocene hominoid from Thailand and orangutan origins

Yaowalak Chaimanee
Dominique Jolly
Jean-Jacques Jaeger
Research06 Mar 2003
Nature

Volume: 422, P: 61-65
Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Julien Barc
Rafik Tadros
Connie R. Bezzina
Amendments and Corrections26 Apr 2022
Nature Genetics

Volume: 54, P: 735
G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus

Certain pathogenic bacteria such as Brucella abortus undergo a temporary non-proliferative stage after infecting host cells. Here, the authors study chromosomal replication and segregation in B. abortusduring infection, showing that the non-proliferative stage consists of G1-arrested newborn cells.

Michaël Deghelt
Caroline Mullier
Xavier De Bolle
ResearchOpen Access09 Jul 2014
Nature Communications

Volume: 5, P: 1-12
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Connie Bezzina, Richard Redon and colleagues show that common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disorder with high risk of sudden cardiac death. The newly discovered loci have a large cumulative effect on disease risk and illustrate how common variants can have a strong impact on predisposition to rare diseases.

Connie R Bezzina
Julien Barc
Richard Redon
Research21 Jul 2013
Nature Genetics

Volume: 45, P: 1044-1049
A simple rule governs the evolution and development of hominin tooth size

The inhibitory cascade, an activator–inhibitor mechanism that affects relative tooth size in mammals, produces the default pattern of tooth sizes for all lower primary postcanine teeth in hominins.

Alistair R. Evans
E. Susanne Daly
Jukka Jernvall
Research24 Feb 2016
Nature

Volume: 530, P: 477-480
Multiple neuroendocrine tumours in transgenic mice induced by c-kit-SV40 T antigen fusion genes

Philippe Bossé
Florence Bernex
Jean-Jacques Panthier
Research05 Jun 1997
Oncogene

Volume: 14, P: 2661-2670
Multi-isotope analysis of bone collagen of Late Pleistocene ungulates reveals niche partitioning and behavioural plasticity of reindeer during MIS 3

Kate Britton
Elodie-Laure Jimenez
Marie Soressi
ResearchOpen Access21 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

Roddy Walsh
Najim Lahrouchi
Connie R. Bezzina
ResearchOpen Access07 Sept 2020
Genetics in Medicine

Volume: 23, P: 47-58
Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus

Elise Bordet
Pauline Maisonnasse
Nicolas Bertho
ResearchOpen Access05 Jul 2018
Scientific Reports

Volume: 8, P: 1-11
Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

Marion Borey
Fany Blanc
Claire Rogel-Gaillard
ResearchOpen Access22 Jul 2021
npj Vaccines

Volume: 6, P: 1-15
Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

Thomas D Gilmore
Catherine Cormier
Maria-Emily Gapuzan
Research01 Nov 2001
Oncogene

Volume: 20, P: 7098-7103

Search

Accelerated drug development using a digital formulator and a self-driving tableting data factory

Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Genetic testing and quality control in diagnostic laboratories

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

A Middle Miocene hominoid from Thailand and orangutan origins

Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

A simple rule governs the evolution and development of hominin tooth size

Multiple neuroendocrine tumours in transgenic mice induced by c-kit-SV40 T antigen fusion genes

Multi-isotope analysis of bone collagen of Late Pleistocene ungulates reveals niche partitioning and behavioural plasticity of reindeer during MIS 3

Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus

Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

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