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Showing 1–2 of 2 results
Advanced filters: Author: Jean-Noël Grad Clear advanced filters

  • Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal, the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine.

    • Annika Meiners
    • Sandra Bäcker
    • Shirley K. Knauer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The Hedgehog morphogen creates gradients during development, but diffusion alone cannot explain its spatiotemporal dynamics. Hedgehog transport requires binding heparan sulfate sugar chains, and the authors now show that Hedgehogs can spread by interacting with sequential heparan molecules.

    • Fabian Gude
    • Jurij Froese
    • Kay Grobe
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15