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Advanced filters: Author: Jean-Philippe Brouland Clear advanced filters

Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation

Joyce and colleagues use bulk and single-cell profiling of T cell phenotypes in human samples from primary brain tumors and brain metastases as a resource for understanding the biology and therapeutic relevance of the brain tumor microenvironment.

Vladimir Wischnewski
Roeltje R. Maas
Johanna A. Joyce
ResearchOpen Access22 May 2023
Nature Cancer

Volume: 4, P: 908-924
An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples

Bulk tumor preservation and dissociation enable multiple analyses of the brain tumor immune microenvironment via immunofluorescent staining and cell sorting followed by transcriptomics, genomics or in vitro culture of specific cell populations.

Roeltje R. Maas
Klara Soukup
Johanna A. Joyce
Protocols30 Aug 2021
Nature Protocols

Volume: 16, P: 4692-4721

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Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation

An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples

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