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Showing 1–17 of 17 results
Advanced filters: Author: Jeff Coller Clear advanced filters

  • The levels of messenger RNA are determined by the rates of RNA decay and transcription, but although the details of transcriptional regulation are increasingly understood, the mechanism(s) controlling mRNA decay remain unclear. In yeast, it is hypothesized that ribosomes must be removed from mRNA before transcripts are destroyed. However, here it is shown that decay takes place while mRNAs are associated with actively translating ribosomes, allowing the last translocating ribosome to complete translation.

    • Wenqian Hu
    • Thomas J. Sweet
    • Jeff Coller
    Research
    Nature
    Volume: 461, P: 225-229

  • Nonsense-mediated mRNA decay (NMD) recognizes and degrades mRNAs with premature termination codons. In yeast, this occurs by decapping followed by 5' to 3' exonucleolytic digestion. New work shows that substrates of NMD pathway are targeted for decapping while the mRNA is associated with polyribosomes. These findings are in contrast to previous work which suggested that NMD occurs in ribosome-free P bodies but are consistent with recent work showing that 'normal' mRNAs are decapped co-translationally.

    • Wenqian Hu
    • Christine Petzold
    • Kristian E Baker
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 244-247

  • Post-transcriptional mRNA regulation is often attained by lengthening or shortening the 3′ poly(A) tail of a transcript. Eukaryotic mRNAs show a spectrum of deadenylation rates, thus allowing intricate control of gene expression, but the mechanisms that determine such rates are unclear. Three new studies highlight the structural and biochemical features of a key enzyme in removing poly(A) tails, the PAN2–PAN3 complex, providing clues to how different mRNA deadenylation rates can be achieved.

    • Sophie Martin
    • Jeff Coller
    News & Views
    Nature Structural & Molecular Biology
    Volume: 21, P: 577-578

  • The relative abundance of specific tRNA can impact protein production rate, folding, and messenger RNA stability. Here the authors describe QuantM-tRNA seq — a method to monitor tRNA abundance and sequence variants — and uncover distinctions in isodecoder expression between tissues that are independent of the anticodon pool of each tRNA family.

    • Otis Pinkard
    • Sean McFarland
    • Jeff Coller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Antibodies directed against citrullinated proteins are commonly found in patients with rheumatoid arthritis. Here, the authors show that citrullination alters the peptide repertoire presented to T cells by altering protease cleavage and inducing protein destabilization, thereby exposing cryptic epitopes.

    • Ashley M. Curran
    • Alexander A. Girgis
    • Erika Darrah
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • The potential of harnessing tRNAs to treat genetic diseases has recently gained significant attention. Here, Coller and Ignatova provide an overview of the history and potential applications of tRNA-based therapies, summarize advances in tRNA cargo design and delivery strategies, and assess the challenges encountered in establishing tRNAs as effective and safe therapeutics.

    • Jeff Coller
    • Zoya Ignatova
    Reviews
    Nature Reviews Drug Discovery
    Volume: 23, P: 108-125

  • The degradation of mRNAs involves removal of the 5′ protective cap via a decapping-enzyme complex, in a largely irreversible process that commits the transcript for destruction. Understanding how the decapping reaction is catalyzed and regulated are major goals in the field. New data suggest how the chemistry of decapping is controlled and orchestrated within the cell.

    • Jeff Coller
    News & Views
    Nature Structural & Molecular Biology
    Volume: 23, P: 954-956

  • The uneven use of the synonymous amino acid codons in the transcriptome coupled with the relative concentrations of different tRNA species gives rise to non-uniform codon decoding rates by ribosomes, known as codon optimality. Codon optimality influences translation efficiency and fidelity, protein folding and mRNA decay.

    • Gavin Hanson
    • Jeff Coller
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 20-30

  • In addition to their roles in chromatin regulation, long non-coding RNAs (lncRNAs) are being characterized as regulators of diverse cell biological processes, including post-transcriptional control, organization of scaffolds and cell signalling. These findings add weight to the notion that lncRNAs provide a flexible resource for rapid cellular control.

    • Sarah Geisler
    • Jeff Coller
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 699-712

  • Although deadenylation induces translational inhibition and mRNA decay, well-expressed transcripts are now shown to possess short, well-defined poly(A) tails, suggesting that pruned tails may be ideal for protective and translational functions.

    • Sarah Azoubel Lima
    • Laura B Chipman
    • Amy E Pasquinelli
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 1057-1063

  • This Review discusses mechanistic insights into 5´–3´ RNA decay, such as translation–decay coupling, coordination between complexes that process 5´ & 3´ RNA termini, conformational control of enzymatic activity, phase separation, & RNA modifications.

    • Jeffrey S. Mugridge
    • Jeff Coller
    • John D. Gross
    Reviews
    Nature Structural & Molecular Biology
    Volume: 25, P: 1077-1085

  • Recent studies have revolutionized our understanding of the interplay between mRNA poly(A) tails and the processes of translation and mRNA decay in the cytoplasm. Poly(A) tails interact with dedicated RNA-binding proteins and deadenylases, which together determine the impact of poly(A) tails on gene expression.

    • Lori A. Passmore
    • Jeff Coller
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 93-106

  • While many mechanisms have been proposed for microRNAs (miRNAs) function, most ultimately cause message degradation. A view has emerged that miRNAs silence gene expression by promoting the association of mRNA decay factors. Recent research results, however, suggest that in both zebrafish and fruit fly, translational inhibition is the initiating event of miRNA-mediated gene silencing.

    • Wenqian Hu
    • Jeff Coller
    Research Highlights
    Cell Research
    Volume: 22, P: 1322-1324