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Showing 1–17 of 17 results
Advanced filters: Author: Jeff Nivala Clear advanced filters

  • Tracking raw materials is critical for securing global supply chains, but traditional tags lack in traceability and anticounterfeiting. The authors present a DNATag-based system for secure traceability, featuring error tolerance, mobile phone readability, and robust forgery protection.

    • Jiaming Li
    • Alex Crown
    • Yuan-Jyue Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Throughout evolution, DNA has been the primary medium of biological information storage. In this article, Ceze, Nivala and Strauss discuss how DNA can be adopted as a storage medium for custom data, as a potential future complement to current data storage media such as computer hard disks, optical disks and tape. They discuss strategies for coding, decoding and error correction and give examples of implementation both in vitro and in vivo.

    • Luis Ceze
    • Jeff Nivala
    • Karin Strauss
    Reviews
    Nature Reviews Genetics
    Volume: 20, P: 456-466

  • A technique for threading long protein strands through a nanopore by electrophoresis and back using a protein unfoldase motor, ClpX, enables single protein molecules to be analyzed multiple times with single-amino-acid sensitivity.

    • Keisuke Motone
    • Daphne Kontogiorgos-Heintz
    • Jeff Nivala
    ResearchOpen Access
    Nature
    Volume: 633, P: 662-669

  • Toe-hold-mediated strand displacement (DSD) is a widely used molecular tool in applications such as DNA computing and nucleic acid diagnostics. Here the authors characterize dozens of orthogonal barcode sequences that can be used for monitoring the output kinetics of multiplexed DSD reactions in real-time using a commercially-available portable nanopore array device.

    • Karen Zhang
    • Yuan-Jyue Chen
    • Jeff Nivala
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Nanopore sequencing combined with DNA-barcoded probes enables multiplexed detection of diverse biomarkers in blood serum.

    • Ashley Stephenson
    • Jeff Nivala
    News & Views
    Nature Nanotechnology
    Volume: 18, P: 1385-1386

  • The nanopore community is stepping toward a new frontier of single-molecule protein sequencing. Here, we offer our opinions on the unique potential for this emerging technology, with a focus on single-cell proteomics, and some challenges that must be overcome to realize it.

    • Keisuke Motone
    • Jeff Nivala
    Comments & Opinion
    Nature Methods
    Volume: 20, P: 336-338

  • Synthetic DNA is the basis for promising technologies in data storage, barcoding, computing 62 and sercurity. In this review, the authors provide an overview of the field and its future.

    • Linda C. Meiser
    • Bichlien H. Nguyen
    • Robert N. Grass
    ReviewsOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The commercialization of DNA tagging is a growing trend that demonstrates the increasing practicality of this novel approach. This interdisciplinary technology is based on the distinctive characteristics of DNA as a molecule that can remain stable in varying environmental conditions and store data following appropriate preparation. Moreover, newly developed technologies could simplify DNA synthesis and the encoding of data within DNA. The implementation of DNA tagging presents distinctive benefits in comparison to conventional labelling techniques, including universal product code (UPC) barcoding, radio-frequency identification (RFID), quick response (QR) codes, and Bluetooth technologies, by surmounting the limitations encountered by these systems. The discourse pertains to extant DNA-tagging mechanisms along with prospective implementations in a wide range of domains, including but not limited to art, the metaverse, forensics, wildlife monitoring, and the military. The potential of DNA labelling in various contexts underscores the importance of continued research and development in this rapidly evolving field.

    • Adam Kuzdraliński
    • Marek Miśkiewicz
    • Bogdan Księżopolski
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 14, P: 1-7