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Showing 1–2 of 2 results
Advanced filters: Author: Jeffery M. Tharp Clear advanced filters

  • Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibitors of SIRT2.

    • Jeffery M. Tharp
    • J. Trae Hampton
    • Wenshe Ray Liu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Phage-assisted evolution can rapidly improve the efficiency and substrate specificity of orthogonal aminoacyl-tRNA synthetases. Furthermore, the crystal structure of the pyrrolysyl-tRNA synthetase N-terminal domain reveals the basis for these improvements and provides a structural rationale for orthogonality.

    • Jeffery M Tharp
    • Wenshe R Liu
    News & Views
    Nature Chemical Biology
    Volume: 13, P: 1205-1206