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Showing 1–26 of 26 results
Advanced filters: Author: Jeffrey J Fredberg Clear advanced filters

  • The mechanical stresses within and between cells inside an advancing cellular monolayer are mapped experimentally. Cellular migration is found to be oriented in the direction of maximum principal stress indicating that cells collectively migrate to maintain minimal local intercellular shear stress.

    • Dhananjay T. Tambe
    • C. Corey Hardin
    • Xavier Trepat
    Research
    Nature Materials
    Volume: 10, P: 469-475

  • The most abundant proteins in our cells are there to generate mechanical forces, and measurement of these forces has just become possible.

    • Xavier Trepat
    • Ben Fabry
    • Jeffrey J Fredberg
    News & Views
    Nature Methods
    Volume: 7, P: 963-965

  • It has been thought that sheets of cells move by traction forces exerted by the cells at the leading edge of the sheet. Using traction microscopy to create a map of physical forces, it is now shown that in fact it is cells many rows from the front that do most of the work.

    • Xavier Trepat
    • Michael R. Wasserman
    • Jeffrey J. Fredberg
    Research
    Nature Physics
    Volume: 5, P: 426-430

  • How the cell goes about its routine mechanical business of stretching, contracting, and remodelling has implications for understanding excessive airway narrowing in asthma, cell invasion in cancer and vessel constriction in vascular disease. Surprisingly, the cell is an intermediate form of matter, neither solid nor fluid but retaining features of both - that responds to stretch by fluidizing, much as do common pastes, foams, clays, and colloids.

    • Xavier Trepat
    • Linhong Deng
    • Jeffrey J. Fredberg
    Research
    Nature
    Volume: 447, P: 592-595

  • During repair, development, or cancer metastasis, epithelial cells can become migratory through partial or full epithelial to mesenchymal transition (EMT). Here, the authors report that differentiated epithelial collectives may undergo cooperative and collective migration without evidence of partial EMT through an unjamming transition (UJT).

    • Jennifer A. Mitchel
    • Amit Das
    • Jin-Ah Park
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Cell shape provides a structural signature for the classification and investigation of the jamming of bronchial epithelial layers in asthma.

    • Jin-Ah Park
    • Jae Hun Kim
    • Jeffrey J. Fredberg
    Research
    Nature Materials
    Volume: 14, P: 1040-1048

  • To drive its migration through a fibrillar matrix—and thus to spread, invade or metastasize—a cancer cell must exert physical forces. The first visualization of these forces in three dimensions reveals surprising migration dynamics.

    • Karin Wang
    • Li-Heng Cai
    • Jeffrey J Fredberg
    News & Views
    Nature Methods
    Volume: 13, P: 124-125

  • A platform for probing the mechanics and migratory dynamics of a growing model breast cancer reveals that cells at the invasive edge are faster, softer and larger than those in the core. Eliminating the softer cells delays the transition to invasion.

    • Yu Long Han
    • Adrian F. Pegoraro
    • Ming Guo
    Research
    Nature Physics
    Volume: 16, P: 101-108

  • Although the collective cellular motion involved in, for example, wound healing and tumour invasion is suspected to be driven by mechanical stresses within the advancing cell monolayer, how motion and stress relate has remained elusive. Now, stress-microscopy observations of an epithelial cell sheet advancing towards a region where cells cannot adhere reveal that the cells located nearby such a region exert forces that pull them towards the unfilled space, regardless of whether the cells approach or recede from it.

    • Jae Hun Kim
    • Xavier Serra-Picamal
    • Jeffrey J. Fredberg
    Research
    Nature Materials
    Volume: 12, P: 856-863

  • Epithelial cells are shown to scale via a shape distribution that is common to a number of different systems, suggesting that cell shape and shape variability are constrained through a relationship that is purely geometrical.

    • Lior Atia
    • Dapeng Bi
    • Jeffrey J. Fredberg
    Research
    Nature Physics
    Volume: 14, P: 613-620

  • At tissue boundaries, cellular repulsive events are manifested as deformation waves that result from an oscillatory pattern of traction forces and intracellular stress that pull cellular adhesions away from the boundary.

    • Pilar Rodríguez-Franco
    • Agustí Brugués
    • Xavier Trepat
    Research
    Nature Materials
    Volume: 16, P: 1029-1037

  • Tissue growth and regrowth rely on the collective migration of sheets of cells. Gradients in tension established through intercellular forces guide this migration, but the mechanism driving the gradients has remained unclear. Innovative experiments now reveal their origin—in a mechanical wave set up by sequential cell reinforcement and fluidization.

    • Xavier Serra-Picamal
    • Vito Conte
    • Xavier Trepat
    Research
    Nature Physics
    Volume: 8, P: 628-634

  • The cytoplasm of living cells responds to deformation in much the same way as a water-filled sponge does. This behaviour, although intuitive, is connected to long-standing and unsolved fundamental questions in cell mechanics.

    • Enhua H. Zhou
    • Fernando D. Martinez
    • Jeffrey J. Fredberg
    News & Views
    Nature Materials
    Volume: 12, P: 184-185