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Showing 1–20 of 20 results
Advanced filters: Author: Jeffrey S. Kieft Clear advanced filters

  • Metal ions that link phosphates and guanine bases are necessary for the folding of an RNA enzyme. A magnesium ion core may be a common feature of RNA structure.

    • Ignacio Tinoco Jr
    • Jeffrey S. Kieft
    News & Views
    Nature Structural Biology
    Volume: 4, P: 509-512

  • A eukaryotic viral internal ribosome entry site (IRES) element is described that binds both bacterial and eukaryotic ribosomes and initiates translation in both, demonstrating that RNA structure-based initiation can occur in both these domains of life, although in bacteria the element uses a mechanism that differs from that in eukaryotes.

    • Timothy M. Colussi
    • David A. Costantino
    • Jeffrey S. Kieft
    Research
    Nature
    Volume: 519, P: 110-113

  • RNA molecules can perform multiple functions, which can be driven by different conformational states; here, the crystal structure of the transfer-RNA-like structure of the turnip yellow mosaic virus is solved, providing insight into the structural basis of RNA multifunctionality.

    • Timothy M. Colussi
    • David A. Costantino
    • Jeffrey S. Kieft
    Research
    Nature
    Volume: 511, P: 366-369

  • Complex RNA three-dimensional structures undergo functionally important programmed conformational changes. Here, the authors report how two structurally and functionally coupled RNA domains within a viral 3′-UTR sense the ribosome through conformational changes and respond by modulating translation.

    • Erik W. Hartwick
    • David A. Costantino
    • Jeffrey S. Kieft
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Many flaviviruses generate specialized non-coding RNAs that resist degradation by host exonucleases, promoting viral infection. Here, the authors characterize an RNA element in Powassan virus, highlighting structural adaptations enabling nuclease resistance and viral persistence.

    • Conner J. Langeberg
    • Matthew J. Szucs
    • Jeffrey S. Kieft
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The cellular 'alarmone' molecule ZTP accumulates when a critical cellular metabolic pathway is starved for substrate. The high-resolution structure of ZTP bound to its RNA-based sensor reveals unexpected strategies used by RNA to specifically recognize small-molecule ligands within the complex cellular mixture.

    • Marisa D Ruehle
    • Jeffrey S Kieft
    News & Views
    Nature Structural & Molecular Biology
    Volume: 22, P: 754-756

  • Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally distinct sfRNA classes in flaviviruses.

    • Andrea MacFadden
    • Zoe O’Donoghue
    • Jeffrey S. Kieft
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Eukaryotic viruses have evolved a variety of ways to manipulate the cellular translation apparatus. In this Review, Jaafar and Kieft present important examples of viral RNA-based strategies to exploit the cellular translation machinery.

    • Zane A. Jaafar
    • Jeffrey S. Kieft
    Reviews
    Nature Reviews Microbiology
    Volume: 17, P: 110-123

  • Studies of the hepatitis C virus internal ribosome entry site (IRES) mechanism have focused on how IRES assembles an 80S ribosome at the start codon. Structural and functional analyses demonstrate that mutations of an IRES domain that docks in the 40S subunit's decoding groove cause conformational changes and that the mutated domain decreases IRES activity by inhibiting ribosome translocation and, thereby, translation elongation.

    • Megan E Filbin
    • Breanna S Vollmar
    • Jeffrey S Kieft
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 150-158

  • Automated 3D design produces rapid and near-atomically accurate predictions of RNA tertiary structure as well as the ability to generate complex RNA machines such as functional single-stranded tethered ribosomes, and enhancement of the binding properties of small-molecule RNA aptamers.

    • Joseph D. Yesselman
    • Daniel Eiler
    • Rhiju Das
    Research
    Nature Nanotechnology
    Volume: 14, P: 866-873

  • Flock House virus protein B2 suppresses the RNA-mediated interference response by binding double-stranded RNA of almost any size or sequence. The crystal structure of this protein bound to RNA reveals a novel fold that suggests its mechanism of action.

    • Jeffrey S Kieft
    • Jennifer S Pfingsten
    News & Views
    Nature Structural & Molecular Biology
    Volume: 12, P: 938-939

  • The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

    • Fan Bu
    • Yagoub Adam
    • Zhichao Miao
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 399-411

  • Here, the authors discuss dual-reporter systems and confounding variables that may lead to misinterpretation of results. They propose guidelines for robust design, physiological interpretation and accurate reporting when using dual reporters.

    • Gary Loughran
    • Dmitry E. Andreev
    • Pavel V. Baranov
    Reviews
    Nature Structural & Molecular Biology
    Volume: 32, P: 418-430